Document Detail

Does endothelin-1 play a role in the pathogenesis of cerebral vasospasm?
MedLine Citation:
PMID:  8160238     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelin-1 is a very powerful endogenous vasoconstrictor substance produced by endothelial cells. Its long-lasting vasoconstrictor and hypertensive action has been well documented in several species, including humans. SUMMARY OF REVIEW: It is generally accepted that endothelin-1 may contribute to the pathogenesis of a number of cardiovascular diseases. In the cerebral vasculature, endothelin-1 has been proposed as a key mediator of cerebral vasospasm following subarachnoid hemorrhage. Availability of endothelin-1 antagonist provided a pharmacologic tool to test the role of endothelin in the development of vasospasm. CONCLUSIONS: This brief review is focused on the controversial results reported by different groups concerning the possible role of endothelin-1 in narrowing of cerebral arteries exposed to autologous blood.
F Cosentino; Z S Katusić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  25     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-13     Completed Date:  1994-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  904-8     Citation Subset:  IM    
Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905.
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MeSH Terms
Azepines / therapeutic use
Endothelins / metabolism*
Indoles / therapeutic use
Ischemic Attack, Transient / etiology,  metabolism*,  prevention & control
Oligopeptides / therapeutic use
Peptides, Cyclic / therapeutic use
Receptors, Endothelin / antagonists & inhibitors
Subarachnoid Hemorrhage / metabolism
Grant Support
Reg. No./Substance:
0/Azepines; 0/Endothelins; 0/Indoles; 0/Oligopeptides; 0/Peptides, Cyclic; 0/Receptors, Endothelin; 136553-81-6/cyclo(Trp-Asp-Pro-Val-Leu); 141594-26-5/BQ 485; 142375-60-8/FR 139317

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