Document Detail

Does endothelial dysfunction contribute to the clinical status of patients with peripheral arterial disease?
MedLine Citation:
PMID:  20386761     Owner:  NLM     Status:  MEDLINE    
Peripheral arterial disease leads to lower extremity ischemia and limb loss, and is linked to cardiovascular events. The anatomical extent of lower extremity atherosclerosis fails to fully explain ischemic symptoms or predict the development of critical limb ischemia. Endothelial dysfunction is known to contributed to the pathogenesis and clinical expression of coronary artery disease, but the importance of endothelial dysfunction in peripheral arterial disease remains incompletely understood. Endothelial dysfunction could contribute to lower extremity ischemia by impairing blood flow responses to ischemia, collateral formation and arterial remodelling, and by promoting vasospasm, thrombosis, plaque rupture and lesion progression. There is a need for additional studies examining the contribution of endothelial dysfunction to the pathogenesis of peripheral arterial disease, and the potential role of endothelial dysfunction as a surrogate marker with utility in the management of patients.
Joseph A Vita; Naomi M Hamburg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  26 Suppl A     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-05-27     Revised Date:  2014-06-16    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  45A-50A     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Endothelium, Vascular / physiopathology*
Lower Extremity / blood supply*
Peripheral Vascular Diseases / physiopathology*
Regional Blood Flow
Grant Support
1UL1RR025771/RR/NCRR NIH HHS; HL081587/HL/NHLBI NIH HHS; HL083269/HL/NHLBI NIH HHS; HL083801/HL/NHLBI NIH HHS; HL75795/HL/NHLBI NIH HHS; K12 HL083781/HL/NHLBI NIH HHS; K12 HL083781/HL/NHLBI NIH HHS; K12 HL083781-01/HL/NHLBI NIH HHS; K12 HL083781-02/HL/NHLBI NIH HHS; K12 HL083781-03/HL/NHLBI NIH HHS; K12 HL083781-04/HL/NHLBI NIH HHS; P01 HL081587/HL/NHLBI NIH HHS; P01 HL081587-010005/HL/NHLBI NIH HHS; P01 HL081587-020005/HL/NHLBI NIH HHS; P01 HL081587-030005/HL/NHLBI NIH HHS; P01 HL081587-040005/HL/NHLBI NIH HHS; P01 HL081587-050005/HL/NHLBI NIH HHS; P50 HL083801/HL/NHLBI NIH HHS; P50 HL083801-01/HL/NHLBI NIH HHS; P50 HL083801-017464/HL/NHLBI NIH HHS; P50 HL083801-02/HL/NHLBI NIH HHS; P50 HL083801-03/HL/NHLBI NIH HHS; P50 HL083801-04/HL/NHLBI NIH HHS; P50 HL083801-05/HL/NHLBI NIH HHS; R01 HL075795/HL/NHLBI NIH HHS; R01 HL075795-01/HL/NHLBI NIH HHS; R01 HL075795-02/HL/NHLBI NIH HHS; R01 HL075795-03/HL/NHLBI NIH HHS; R01 HL075795-05/HL/NHLBI NIH HHS; R01 HL083269/HL/NHLBI NIH HHS; R01 HL083269-01A1/HL/NHLBI NIH HHS; R01 HL083269-02/HL/NHLBI NIH HHS; R01 HL083269-03/HL/NHLBI NIH HHS; R01 HL083269-04/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Biological Markers

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