Document Detail

Does dynamic immobilization reduce chondrocyte apoptosis and disturbance to the femoral head perfusion?
MedLine Citation:
PMID:  23330006     Owner:  NLM     Status:  MEDLINE    
The purpose of this study is to investigate whether the dynamic hip immobilization is more favourable for lessening ischemic injury to the immature femoral head than a static immobilization. 152 Japanese white rabbits were divided into four groups randomly, and the hips were immobilized into "human" position (group A), "frog leg" position (group B) and "dynamic frog leg" position (group C). Group D was used as control. Ten rabbits in each group were killed, and the hip specimens were harvested at 1, 2, and 3 weeks after immobilization. Bcl-2/Bax expression balance and chondrocytes apoptosis were analyzed. The remaining eight rabbits in each group were used to measure the blood supply of capital femoral epiphysis by selective vascular perfusion with Indian ink. The Bcl-2/Bax expression ratio in group C was significantly increased than that in group A and B (p<0.001), while that was not significantly different from control group (p=0.0592). At three weeks after immobilization, the average apoptotic ratio was 36.7%, 45.8%, and 26.7% in group A, B and C, respectively (p<0.01). There was no significant difference between group C and normal control (p=0.0597). The perfusion ratio was 0.03±0.03, 0.03±0.02, and 0.08±0.03 in group A, B and C respectively, and 0.12±0.04 in control group (p<0.05). Thus, the dynamic immobilization model exhibited a relatively less chondrocytes apoptosis and disturbance to the femoral head perfusion than other immobilizations in vivo, which therefore may be useful for reducing avascular necrosis following the treatment of developmental dysplasia of the hip.
Lian-Yong Li; Li-Jun Zhang; Jing-Yu Jia; Qun Zhao; En-Bo Wang; Qi-Wei Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-15
Journal Detail:
Title:  International journal of clinical and experimental pathology     Volume:  6     ISSN:  1936-2625     ISO Abbreviation:  Int J Clin Exp Pathol     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-07-09     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101480565     Medline TA:  Int J Clin Exp Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-23     Citation Subset:  IM    
Department of Pediatric Orthopedics, Shengjing Hospital of China Medical University Shenyang City, Liaoning Province, PR China.
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MeSH Terms
Apoptosis / physiology*
Casts, Surgical / adverse effects
Chondrocytes / pathology*
Disease Models, Animal
Epiphyses / blood supply,  growth & development,  metabolism
Femur / blood supply,  growth & development,  metabolism
Femur Head Necrosis / pathology*,  prevention & control*
Hindlimb Suspension / adverse effects*,  methods*
Hip Dislocation, Congenital / therapy
Hip Joint / blood supply,  growth & development
Ischemia / pathology,  prevention & control
Proto-Oncogene Proteins c-bcl-2 / metabolism
bcl-2-Associated X Protein / metabolism
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein

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