| Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD? | |
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MedLine Citation:
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PMID: 22183485 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dynamic hyperinflation (DH) during exercise occurs in most but not all patients with advanced COPD. It is not known whether the presence or absence of DH has implications for dyspnoea and exercise tolerance. Therefore, we compared detailed ventilatory and sensory responses to exercise in hyperinflators and non-hyperinflators with moderate to severe COPD.Non-hyperinflators (n=65) were retrospectively identified from a sample of 427 patients and case-matched to a group of hyperinflators (n=65) based on sex, age, body mass index and %predicted forced expiratory volume in 1 second. Resting pulmonary function and constant work rate cycle exercise responses were compared.Hyperinflators decreased inspiratory capacity (IC) from rest to peak exercise by 0.46±0.24 L whereas the non-hyperinflators increased IC by 0.10±0.15 L (P<0.0001). There were no significant group differences in endurance time (9.11±5.98 vs. 8.87±5.24 min) or dyspnoea intensity for any given time or ventilation. An inflection in tidal volume versus ventilation occurred in the majority of non-hyperinflators (n=61) and hyperinflators (n=62) at a similar time and ventilation. Mechanical constraints on tidal volume expansion and the attendant rise in dyspnoea intensity were similar in both groups.Dyspnoea intensity during exercise was associated with progressive mechanical constraints on tidal volume expansion regardless of the presence of DH. |
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Authors:
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J A Guenette; K A Webb; D E O'Donnell |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: - ISSN: 1399-3003 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dept of Medicine, Queen's University and Kingston General Hospital, Kingston, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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