Document Detail

Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?
MedLine Citation:
PMID:  22183485     Owner:  NLM     Status:  MEDLINE    
Dynamic hyperinflation (DH) during exercise occurs in most but not all patients with advanced chronic obstructive pulmonary disease (COPD). It is not known whether the presence or absence of DH has implications for dyspnoea and exercise tolerance. Therefore, we compared detailed ventilatory and sensory responses to exercise in hyperinflators and nonhyperinflators with moderate-to-severe COPD. Nonhyperinflators (n=65) were retrospectively identified from a sample of 427 patients and case-matched to a group of hyperinflators (n=65) based on sex, age, body mass index and % predicted forced expiratory volume in 1 s. Resting pulmonary function and constant work rate cycle exercise responses were compared. Hyperinflators decreased inspiratory capacity (IC) from rest to peak exercise by 0.46±0.24 L whereas the nonhyperinflators increased IC by 0.10±0.15 L (p<0.0001). There were no significant group differences in endurance time (9.11±5.98 versus 8.87±5.24 min) or dyspnoea intensity for any given time or ventilation. An inflection in tidal volume versus ventilation occurred in the majority of nonhyperinflators (n=61) and hyperinflators (n=62) at a similar time and ventilation. Mechanical constraints on tidal volume expansion and the attendant rise in dyspnoea intensity were similar in both groups. Dyspnoea intensity during exercise was associated with progressive mechanical constraints on tidal volume expansion regardless of the presence of DH.
Jordan A Guenette; Katherine A Webb; Denis E O'Donnell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-19
Journal Detail:
Title:  The European respiratory journal     Volume:  40     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-10     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  322-9     Citation Subset:  IM    
Respiratory Investigation Unit, Queen's University and Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L-2V7, Canada.
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MeSH Terms
Body Mass Index
Case-Control Studies
Dyspnea / complications*,  physiopathology
Exercise Test
Exercise Tolerance
Forced Expiratory Volume / physiology
Inspiratory Capacity
Middle Aged
Pulmonary Disease, Chronic Obstructive / complications*,  physiopathology
Retrospective Studies
Time Factors
Comment In:
Eur Respir J. 2012 Aug;40(2):283-5   [PMID:  22855464 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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