Document Detail

Does dobutamine improve ventricular function in dogs with regional myocardial dysfunction?
MedLine Citation:
PMID:  12088936     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: We examined the effect of systemic dobutamine on regional wall motion abnormalities (RWMAs) induced by intracoronary esmolol infusion in eight anesthetized dogs. Esmolol dilated the heart and decreased regional synchrony of contraction. Dobutamine restored cardiac function but failed to correct the asynchrony of regional contraction caused by esmolol-induced RWMAs.
David P Strum; Michael R Pinsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  95     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-28     Completed Date:  2002-07-23     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  19-25, table of contents     Citation Subset:  AIM; IM    
Department of Anesthesiology and Critical Care Medicine, Kingston General Hospital, Queen's University, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Blood Pressure / drug effects
Cardiomyopathies / physiopathology*
Cardiotonic Agents / pharmacology*
Dobutamine / pharmacology*
Dose-Response Relationship, Drug
Heart Conduction System / drug effects
Heart Rate / drug effects
Infusions, Intravenous
Myocardial Contraction / drug effects
Propanolamines / pharmacology
Stroke Volume / physiology
Ventricular Function / drug effects*
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Cardiotonic Agents; 0/Propanolamines; 34368-04-2/Dobutamine; MDY902UXSR/esmolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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