| Does diet in preterm infants influence clinical outcome? | |
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MedLine Citation:
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PMID: 3327529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After several decades of intensive research into feeding preterm infants, it is important to question why there is persisting uncertainty over their dietary management. The evolution of scientific investigation in this field is compared with that in other areas of clinical science, where a three-phase pattern emerges: phase 1, reports of anecdotal observation and clinical experience; phase 2, epidemiological observation and physiological experiment; and phase 3, controlled prospective trials of specific interventions on clinical outcome. It is argued that research into feeding preterm infants has not evolved beyond physiological experiment (phase 2) and that the absence of clinical outcome data (phase 3 research) explains major uncertainties in clinical practice. Data from a large randomized multicentre outcome study of preterm nutrition are used to demonstrate how the wealth of previous and current 'physiological' information cannot be used satisfactorily to predict desirable clinical outcome responses to early diet. |
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Authors:
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A Lucas |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Review |
Journal Detail:
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Title: Biology of the neonate Volume: 52 Suppl 1 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1987 |
Date Detail:
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Created Date: 1988-05-10 Completed Date: 1988-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 141-6 Citation Subset: IM |
Affiliation:
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University of Cambridge, England. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Diet* Humans Infant, Newborn Infant, Premature / metabolism* Nutritional Requirements Prognosis Random Allocation |
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