Document Detail

Does diet in preterm infants influence clinical outcome?
MedLine Citation:
PMID:  3327529     Owner:  NLM     Status:  MEDLINE    
After several decades of intensive research into feeding preterm infants, it is important to question why there is persisting uncertainty over their dietary management. The evolution of scientific investigation in this field is compared with that in other areas of clinical science, where a three-phase pattern emerges: phase 1, reports of anecdotal observation and clinical experience; phase 2, epidemiological observation and physiological experiment; and phase 3, controlled prospective trials of specific interventions on clinical outcome. It is argued that research into feeding preterm infants has not evolved beyond physiological experiment (phase 2) and that the absence of clinical outcome data (phase 3 research) explains major uncertainties in clinical practice. Data from a large randomized multicentre outcome study of preterm nutrition are used to demonstrate how the wealth of previous and current 'physiological' information cannot be used satisfactorily to predict desirable clinical outcome responses to early diet.
A Lucas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Review    
Journal Detail:
Title:  Biology of the neonate     Volume:  52 Suppl 1     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-10     Completed Date:  1988-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
University of Cambridge, England.
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MeSH Terms
Clinical Trials as Topic
Infant, Newborn
Infant, Premature / metabolism*
Nutritional Requirements
Random Allocation

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