Document Detail

Does diagnostic coronary angiography induce significant coronary microembolization in stable, ischemic patients? A prospective study.
MedLine Citation:
PMID:  16881984     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although microembolization during percutaneous coronary interventions is a frequent event, the extent of possible microembolization during diagnostic coronary angiography is unknown. The aim of the study was to investigate whether diagnostic coronary angiography results in coronary microembolization and consequent subtle, subclinical myocardial necrosis with enzyme elevations. METHODS: Fifty-three consecutive patients underwent diagnostic coronary angiography due to inducible ischemia. Creatine kinase MB isoenzyme (CK MB) and cardiac troponin I (cTnI) were used as sensitive surrogate markers of myocardial necrosis. Serial measurements, before, and 6 and 24 hours following a diagnostic procedure, were performed. RESULTS: Baseline cTnI was below the limits of detection in all patients (<0.20 ng/mL), except for one patient with 1.31 ng/mL. Baseline median CK-MB was 1.05 ng/mL (interquartile range, 0.80-1.56 ng/mL) (Fig. 1). Both at 6 and 24 hours, no patients had any increase in cTnI, with the exception of a minor increase to 0.22 ng/mL at 24 hours in one patient. At 6 hours, 25 patients had decreases in CK MB, while 22 had increases (exact P = 0.77). At 24 hours, 26 patients had decreases in CK MB and 19 patients had increases. CONCLUSIONS: Detectable embolization with subsequent subclinical myonecrosis is an unlikely event.
Demosthenes Katritsis; Socrates Korovesis; Evangelia Karvouni; Eleftherios Giazitzoglou; George Paxinos; Alexander Haliassos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  19     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-02     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  IM    
Department of Cardiology, Athens Euroclinic, Athens, Greece.
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MeSH Terms
Coronary Angiography / adverse effects*
Coronary Vessels / metabolism,  pathology*
Creatine Kinase, MB Form / blood
Embolism / blood,  etiology*
Middle Aged
Myocardial Ischemia / blood,  radiography*
Necrosis / blood,  etiology
Prospective Studies
Research Design
Troponin I / blood
Reg. No./Substance:
0/Troponin I; EC Kinase, MB Form

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