| Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy? | |
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MedLine Citation:
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PMID: 20956995 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The objective was to test the hypothesis that in patients with prostate cancer undergoing radical prostatectomy (RP), diabetic patients are at a higher risk of harboring a high-grade tumor than non-diabetic patients. We examined 2060 consecutive men who underwent RP between 2001 and 2009. Of them, 7.1% had type 2 diabetes mellitus (DM). A high-grade tumor was defined as having a Gleason score 8. Univariable and multivariable logistic regression analyses were used to test the relationship between type 2 DM and high-grade tumor. Mean patient age was 64 years (range: 45-85). Mean total PSA level was 9 ng ml(-1) (range: 1-89.5). A significantly higher percentage of diabetic patients had high-grade tumor on biopsy (16.3 vs 7.6%; P=0.001) and on RP specimen (21.1 vs 11.7%; P=0.001) in comparison with non-diabetic patients. In multivariable analyses, DM was an independent predictor of high-grade tumor on biopsy (odds ratio=2.31, P=0.001) and on final pathological specimen (odds ratio=2.22, P=0.002). In patients undergoing RP, those with type 2 DM had a higher risk of harboring a poorly differentiated tumor on final pathological examination. |
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Authors:
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F Abdollah; A Briganti; N Suardi; A Gallina; U Capitanio; A Salonia; A Cestari; G Guazzoni; P Rigatti; F Montorsi |
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Publication Detail:
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Type: Journal Article Date: 2010-10-19 |
Journal Detail:
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Title: Prostate cancer and prostatic diseases Volume: 14 ISSN: 1476-5608 ISO Abbreviation: Prostate Cancer Prostatic Dis. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815755 Medline TA: Prostate Cancer Prostatic Dis Country: England |
Other Details:
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Languages: eng Pagination: 74-8 Citation Subset: IM |
Affiliation:
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Department of Urology, San Raffaele Hospital, Vita-Salute University, Milan, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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