Document Detail

Does dexmedetomidine have a cardiac protective effect during non-cardiac surgery? A randomised controlled trial.
MedLine Citation:
PMID:  25132247     Owner:  NLM     Status:  Publisher    
This study was designed to determine the effects of dexmedetomidine on perioperative myocardial injury by observing peripheral circulatory changes in response to tracheal intubation and extubation, myocardial enzyme levels, myocardial ischemia improvements, cardiovascular adverse events and cytokines in patients with coronary heart disease (CHD) undergoing non-cardiac surgery. This study was a prospective, randomized, double-blind trial. Eighty patients having CHD were scheduled for elective hip replacement surgery and randomly allocated to receive a loading dose of 1μg/kg dexmedetomidine followed with a 0.2 μg/kg/h infusion (Dex group n = 40) or normal saline (Control group n = 40). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), rate pressure product (RPP) and changes of ST-T segment in ECG were recorded every 5 minutes during surgery. Serum creatine kinase-MB(CK-MB), cardiac troponin I(cTnI), glycogen phosphorylase BB(GP-BB), interleukin-6(IL-6) and tumor necrosis factor(TNF-α) protein levels were determined preoperatively, at the end of surgery, 12h post-surgery and 24h post-surgery. The improvement rate of myocardial ischemia (87.5% vs 32.5%, p<0.05) was higher in the dexmedetomidine group than in the control group. The dexmedetomidine group had lower serum CK-MB, IL-6, cTnI and GP-BB concentrations than those in the control group (p<0.05). There was no significance difference in TNF-α between the two groups (p>0.05). Dexmedetomidine can reduce myocardial injury and cytokines levels in patients with CHD undergoing non-cardiac surgery. This article is protected by copyright. All rights reserved.
Lili Xu; Zhiyong Hu; Jianjun Shen; Patrick M McQuillan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-12
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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