Document Detail

Does detraining restore influence of exercise training on microvascular responses in streptozotocin-induced diabetic rats?
MedLine Citation:
PMID:  20880497     Owner:  NLM     Status:  MEDLINE    
METHOD: Male Wistar rats (220±10g, N=85) were made diabetic by streptozotocin (60mg/kg, subcutaneously). One week after diabetes induction, animals were submitted to exercise training for 10weeks on a treadmill and detrained for 5weeks. To characterize cutaneous microvascular responses by Laser Doppler flowmetery, animals were deeply anaesthetized by intra peritoneal injection of pentobarbital sodium and placed on a heating pad, a rectal thermometer was inserted, and body temperature was maintained at 37±0.5°C. A tracheotomy was performed to minimize respiratory difficulties. Results in diabetic rats after training: (1) l-arginine (l-ARG) and Acetylcholine (Ach)-induced cutaneous perfusion were increased. However, these effects were reversed by detraining and Nw-nitro-l-arginine (l-NNA); (2) sodium nitroprusside (SNP)-induced cutaneous perfusion did not significantly change; and (3) cutaneous microvascular responses to SNP were reduced after detraining. The results suggest that in diabetic rats, beneficial effect of regular exercise on cutaneous microvascular endothelium-dependent dilatation and l-ARG/Nitric oxide pathway activity was approximately reversed by 5weeks of detraining. Training did not affect endothelium-independent dilatation; however, detraining reduced it significantly.
Ali Heidarianpour
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Publication Detail:
Type:  Journal Article     Date:  2010-09-27
Journal Detail:
Title:  Microvascular research     Volume:  80     ISSN:  1095-9319     ISO Abbreviation:  Microvasc. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-02-25     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Administration, Cutaneous
Arginine / metabolism
Diabetes Mellitus, Experimental / complications,  metabolism,  physiopathology*
Diabetic Angiopathies / etiology,  metabolism,  physiopathology*
Enzyme Inhibitors / administration & dosage
Laser-Doppler Flowmetry
Microcirculation* / drug effects
Microvessels / metabolism,  physiopathology*
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Physical Exertion*
Rats, Wistar
Skin / blood supply*
Time Factors
Vasodilation* / drug effects
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Vasodilator Agents; 31C4KY9ESH/Nitric Oxide; 94ZLA3W45F/Arginine; EC Oxide Synthase

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