| Does delayed correction interfere with pulmonary functions and exercise tolerance in patients with tetralogy of fallot? | |
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MedLine Citation:
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PMID: 16100200 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: To assess exercise tolerance and determine the distinct role of cardiac, respiratory, or peripheral factors on it after delayed surgical repair in patients with tetralogy of Fallot. DESIGN: The aerobic exercise capacity of 15 adult patients (mean [+/- SD] age, 21 +/- 6; age range, 9 to 30 years) undergoing successful total correction at a mean age of 12 +/- 5 years (patients) was compared to healthy, matched control subjects by using right ventricle echocardiography, resting spirometry, and cardiopulmonary exercise tests at a mean postoperative time of 7.5 +/- 4.6 years. SETTING: Tertiary care referral centers. PATIENTS: Fifteen adult patients (mean age, 21 +/- 6 years; age range, 9 to 30 years) undergoing successful total correction at a mean age of 12 +/- 5 (patients) and 15 healthy, matched volunteers (control subjects). RESULTS: There was evidence for a slight right ventricular diastolic dysfunction in the patients. Mean FVC (88 +/- 9% vs 109 +/- 12% predicted, respectively) and FEV1 (89 +/- 9% vs 109 +/- 12% predicted, respectively), although being within the normal range, were also decreased in comparison to those of control subjects (p < 0.0001). Maximal oxygen consumption (V(O2max) decreased in both groups (55 +/- 16% vs 61 +/- 23% predicted, respectively; p = 0.5); however, there were more individuals with severely decreased values among the patients (p = 0.05). V(O2) at the anaerobic threshold was also decreased in patients (33 +/- 15% vs 51 +/- 8% predicted, respectively; p = 0.004). The maximum tolerable exercise time was 17.3 +/- 4.5 min in patients vs 21.2 +/- 6.4 min in control subjects (p = 0.06). CONCLUSIONS: The exercise capacity after delayed repair was good in general compared to matched control subjects; however, exercise capacity may be slightly limited by ventilatory dysfunction, low anaerobic threshold, and lack of physical fitness despite New York Heart Association class improvement after undergoing the operation. |
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Authors:
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Murat Ercisli; Kerem M Vural; Kutay N Gokkaya; Fusun Koseoglu; Omac Tufekcioglu; Erol Sener; Oguz Tasdemir |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 128 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-09-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1010-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Surgery, Yuksek Ihtisas Hospital of Turkey, Ankara. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Exercise Tolerance* Female Humans Male Respiratory Function Tests Tetralogy of Fallot / physiopathology*, surgery* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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