Document Detail

Does combination therapy with a calcium channel blocker and an ACE inhibitor have additive effects on blood pressure reduction?
MedLine Citation:
PMID:  10824365     Owner:  NLM     Status:  MEDLINE    
Reports in the medical literature have suggested that the effects on blood pressure (BP) of calcium channel blockers (CCBs) and angiotensin-converting enzyme (ACE) inhibitors are additive. Most reports have provided neither a definition of 'additive' nor the necessary information to determine whether the effects are additive. In this review of the medical literature, the effects of combination therapy were defined as additive if the sum of the mean reductions in BP following monotherapy with a CCB and an ACE inhibitor was not significantly different from the mean reduction in BP of combination therapy. The review generally showed that combination therapy is more effective than treatment with either monotherapy alone, based on mean decreases in either diastolic or systolic BP. The studies provided no clear evidence that the effects of combination therapy were either additive or less than additive.
D A Edelman; R A Paul
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical practice     Volume:  54     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-12     Completed Date:  2000-06-12     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  105-9     Citation Subset:  IM    
Scirex Corporation, San Diego, California, USA.
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MeSH Terms
Aged, 80 and over
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / drug effects*
Calcium Channel Blockers / therapeutic use*
Cross-Over Studies
Double-Blind Method
Drug Therapy, Combination
Enalapril / administration & dosage
Hypertension / drug therapy*
Middle Aged
Nifedipine / administration & dosage
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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