Document Detail

Does colorectal cancer clinical advancement affect adhesion molecules (sP-selectin, sE-selectin and ICAM-1) concentration?
MedLine Citation:
PMID:  19136145     Owner:  NLM     Status:  MEDLINE    
Adhesion molecules take part in physiological and pathological processes. They involved in inflammatory reactions and play important role in tumor invasion and the development of metastases. Soluble forms of P-selectin, E-selectin and ICAM-1 have been described in this study in patient with colorectal cancer. Plasma was obtained from 44 patients with colorectal cancer and 34 control subject's prior surgery, by an enzyme-linked immunosorbent assay (ELISA). The patients were divided according to TNM classification. Plasma level of all three molecules was significantly higher in colorectal cancer patients than in the control (p < 0.001). The highest level of sE-selectin and ICAM-1 were observed in patients with liver metastasis. There was no correlation between sP-selectin and sE-selectin, but we found a significant correlation between sE-selectin and ICAM-1 in all patients. These findings suggest that plasma concentration of E-selectin and ICAM-1 may indicate tumor progression and liver metastasis.
V Dymicka-Piekarska; H Kemona
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Publication Detail:
Type:  Journal Article     Date:  2009-01-10
Journal Detail:
Title:  Thrombosis research     Volume:  124     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-3     Citation Subset:  IM    
Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland.
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MeSH Terms
Case-Control Studies
Colorectal Neoplasms / blood*,  pathology*
E-Selectin / blood*
Intercellular Adhesion Molecule-1 / blood*
Liver Neoplasms / blood,  secondary
Neoplasm Staging
P-Selectin / blood*
Practice Guidelines as Topic
Reg. No./Substance:
0/E-Selectin; 0/P-Selectin; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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