Document Detail

Does clozapine cause or worsen obsessive compulsive symptoms? An analysis and literature review.
MedLine Citation:
PMID:  23983945     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Clozapine is the most effective antipsychotic in treatment-resistant schizophrenia but its use portends with a high burden of adverse reactions. One adverse event reported both in case reports and cross-sectional surveys is the emergence or worsening of obsessive compulsive symptoms (OCS).
OBJECTIVES: This study presents a retrospective review of a UK cohort of clozapine-treated individuals with the aim to further investigate the complex relationship between clozapine and OCS.
METHODS: An extensive review of the medical records of 49 patients receiving clozapine in the Southampton area was undertaken. We searched for a diagnosis of obsessive compulsive disorder, signs or symptoms of obsessive compulsive disorder or the prescribing of selected antidepressants the year before clozapine initiation and the year after.
RESULTS: Fifteen patients (31%) had reports of OCS during the 2-year data collection period. Twelve patients (24%) had OCS before clozapine initiation while only 7 (14%) had symptoms after clozapine was initiated. De novo OCS were reported in three (6%) cases after 5-9 months of clozapine treatment.
CONCLUSIONS: As with previous studies it was not possible to establish a definitive link between clozapine and OCS. Clinicians should be mindful of the common comorbidity of OCS and schizophrenia and the possible increased risk incurred when starting clozapine.
Stephen Bleakley; David Brown; David Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in psychopharmacology     Volume:  1     ISSN:  2045-1253     ISO Abbreviation:  Ther Adv Psychopharmacol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2013-08-28     Completed Date:  2013-08-28     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101555693     Medline TA:  Ther Adv Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  -    
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