| Does clofazimine have a prophylactic role against neuritis? | |
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MedLine Citation:
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PMID: 9364824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was undertaken with the aim of testing the usefulness of clofazimine as a prophylactic agent against neuritis and nerve damage. A modified regimen, using initial high doses of clofazimine followed by regular multibacillary multidrug therapy (MB-MDT) WHO regimen, was given to a series of consecutive cases of high risk borderline leprosy patients, fulfilling defined selection criteria (n = 65). These patients were studied for the incidence of neuritis/Type I reaction, over a period of 2 years. Results were compared with a matched series of consecutive cases treated only with regular MB-MDT WHO regimen (n1 = 57). The difference in incidence rates of neuritis between the two groups was significant (p < 0.01), suggesting that clofazimine may have a useful prophylactic role against neuritis/Type I reaction and nerve damage. |
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Authors:
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S Arunthathi; K K Satheesh |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Leprosy review Volume: 68 ISSN: 0305-7518 ISO Abbreviation: Lepr Rev Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-12-15 Completed Date: 1997-12-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0243711 Medline TA: Lepr Rev Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 233-41 Citation Subset: IM |
Affiliation:
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Schieffelin Leprosy Research and Training Centre (SLR&TC), Tamil Nadu, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Case-Control Studies Clofazimine / administration & dosage, therapeutic use* Dapsone / administration & dosage, therapeutic use Drug Therapy, Combination Female Humans Leprostatic Agents / administration & dosage, therapeutic use* Leprosy, Borderline / complications, diagnosis, drug therapy* Male Middle Aged Neuritis / complications, drug therapy*, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Leprostatic Agents; 2030-63-9/Clofazimine; 80-08-0/Dapsone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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