Document Detail

Does chylomicronemia cause atherosclerosis?
MedLine Citation:
PMID:  2048123     Owner:  NLM     Status:  MEDLINE    
Does chylomicronemia cause atherosclerosis? To directly address this clinically important problem, we conducted experiments in guinea pigs which lack apolipoprotein CII and develop chylomicronemia when they are fed a high-fat diet. After 6-12 months on a high-fat diet, guinea pigs were sacrificed, and subjected to histopathological and ultrastructural examination. Both the aorta and the coronary arteries revealed no atherosclerotic changes in all 4 animals examined: the endothelium was intact, and neither lipid-laden foam cells nor migrating cells were present within the arterial wall. Our studies indicate that chylomicronemia does not predispose to atherosclerosis.
T Murase; M Okubo; M Hara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  163     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-18     Completed Date:  1991-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Okinaka Memorial Institute for Medical Research, Tokyo.
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MeSH Terms
Aorta / pathology,  ultrastructure
Arteriosclerosis / blood,  etiology*,  pathology
Cholesterol, Dietary / administration & dosage
Chylomicrons / blood*
Dietary Fats / administration & dosage
Disease Models, Animal
Guinea Pigs
Lipoproteins / blood
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Chylomicrons; 0/Dietary Fats; 0/Lipoproteins; 0/Triglycerides

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