Document Detail


Does chronic mountain sickness (CMS) have perinatal origins?
MedLine Citation:
PMID:  17706469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic mountain sickness (CMS) occurs in approximately 10% of male high-altitude residents. It is characterized by hypoventilation and hypoxemia but its underlying cause remains unknown. We hypothesized that CMS' origins reside in exaggerated perinatal hypoxia that serves, in turn, to impair the development of pulmonary structure and/or respiratory control. As a preliminary test, we asked if birth weights were low and other signs of perinatal hypoxia were present in 12 young men with excessive erythrocytosis (EE, Hb>or=18.3g/dL), a condition thought to be a preclinical phase of CMS. Their birth weights were uniformly low (2571+/-243g) and all but one demonstrated perinatal hypoxia as manifested either by being small for their gestational age (SGA, 8%), preterm (67%), born to a preeclamptic (PE) mother (50%), or diagnosed with neonatal hypoxia (83%). Impaired growth in utero has been shown to raise susceptibility to adult disease; these are the first data to demonstrate a possible influence of reduced fetal growth and/or exaggerated perinatal hypoxia on increasing the susceptibility to CMS. Future studies, with more detailed testing in larger samples of control as well as EE subjects, with longitudinal follow-up, are required to determine the role of perinatal hypoxia in the development of CMS.
Authors:
Lorna G Moore; Susan Niermeyer; Enrique Vargas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-07-07
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  158     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-24     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  180-9     Citation Subset:  IM    
Affiliation:
Altitude Research Center, Department of Surgery/Emergency Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA. Lorna.G.Moore@UCHSC.edu
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology*
Age Factors
Altitude*
Altitude Sickness / etiology,  metabolism*,  physiopathology
Chronic Disease
Fetal Hypoxia / complications*
Hemoglobins / metabolism*
Humans
Male
Oxygen / blood
Oxygen Consumption / physiology*
Grant Support
ID/Acronym/Agency:
HL079647/HL/NHLBI NIH HHS; HL60131/HL/NHLBI NIH HHS; TW001188/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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