Document Detail


Does chronic microaspiration cause idiopathic pulmonary fibrosis?
MedLine Citation:
PMID:  20362747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Idiopathic pulmonary fibrosis is a diffuse fibrotic lung disease of unknown etiology with no effective treatment. Emerging data support a role for chronic microaspiration (ie, subclinical aspiration of small droplets) in the pathogenesis and natural history of idiopathic pulmonary fibrosis. However, the precise relationship between chronic microaspiration and idiopathic pulmonary fibrosis remains unknown. Gastroesophageal reflux, a presumed risk factor for microaspiration, has been strongly associated with idiopathic pulmonary fibrosis with an estimated prevalence of up to 90%. This review aims to describe the relationship between chronic microaspiration and idiopathic pulmonary fibrosis by laying out the clinical and biologic rationale for this relationship and exploring the scientific evidence available. The gaps in our current understanding of the diagnosis of chronic microaspiration and idiopathic pulmonary fibrosis and the ongoing uncertainties in management and treatment will be highlighted. Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological, and treatment implications for this deadly disease.
Authors:
Joyce S Lee; Harold R Collard; Ganesh Raghu; Matthew P Sweet; Steven R Hays; Guilherme M Campos; Jeffrey A Golden; Talmadge E King
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  123     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-04-22     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-11     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chronic Disease
Humans
Idiopathic Pulmonary Fibrosis / etiology*
Respiratory Aspiration / complications*
Grant Support
ID/Acronym/Agency:
F32 HL097383/HL/NHLBI NIH HHS; F32 HL097383-01/HL/NHLBI NIH HHS; HL086516/HL/NHLBI NIH HHS; K23 HL086516-04/HL/NHLBI NIH HHS
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