Document Detail

Does chromostatin influence catecholamine release or blood pressure in vivo?
MedLine Citation:
PMID:  8015978     Owner:  NLM     Status:  MEDLINE    
Although the structure of chromogranin A (CgA) is now known, its ultimate physiological role remains elusive. Recently, an interior fragment of CgA [CgA(124-143)], also called chromostatin, was reported to suppress catecholamine release from chromaffin cells in vitro. We therefore explored chromostatin's biological actions when administered in vivo to anesthetized rodents with normal (Wistar-Kyoto rats) or elevated blood pressure (spontaneously hypertensive rats). Neither mean arterial pressure nor plasma epinephrine concentrations were significantly altered following either chromostatin or vehicle administration. Plasma norepinephrine, on the other hand, tended to rise throughout all studies, with the rise reaching statistical significance only in the SHR subgroup receiving chromostatin. We conclude that, unlike its actions in vitro, chromostatin does not appear to suppress catecholamine release or modulate blood pressure in vivo.
G E Garcia; F B Gabbai; D T O'Connor; T Q Dinh; B Kennedy; M G Ziegler; M A Takiyyuddin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  15     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-7     Citation Subset:  IM    
Department of Medicine, University of California, San Diego 92161.
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MeSH Terms
Blood Pressure / drug effects*
Catecholamines / metabolism*
Chromogranin A
Chromogranins / pharmacology*
Hypertension / drug therapy,  physiopathology*
Peptide Fragments / pharmacology*
Rats, Inbred SHR
Rats, Inbred WKY
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Chromogranin A; 0/Chromogranins; 0/Peptide Fragments; 0/chromostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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