Document Detail

Does changing paternity contribute to the risk of intrauterine growth retardation?
MedLine Citation:
PMID:  9018714     Owner:  NLM     Status:  MEDLINE    
An immune reaction initiated by paternal antigens may be necessary for healthy placental development, pregnancy maintenance and infant growth. An inadequate immune response may result in intrauterine growth retardation (IUGR). We hypothesised that a change in paternity may interfere with the immune response and cause poor placentation with resultant IUGR. In this paper we examine the risk of IUGR associated with changes in paternity. We used the Utah Successive Pregnancies Data Set that contains information on women across their pregnancies. We restricted the analysis to 141,817 women with two or three pregnancies. Women who did not have an IUGR infant in the previous pregnancy were at a 20-30% greater risk of developing IUGR if they had changed partners. Women who had a previous IUGR infant were at no increased risk for IUGR after a change in paternity. These results may point to an immune mechanism or may be as a result of residual confounding of unmeasured risk factors for IUGR. Further studies with data that contain more sociodemographic and biological risk factors for IUGR are necessary to exclude residual confounding.
C J Krulewitch; A A Herman; K F Yu; Y R Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  11 Suppl 1     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Pregnancy and Infant Health Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
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MeSH Terms
Birth Order
Fetal Growth Retardation / epidemiology*,  immunology
Marital Status*
Pregnancy / immunology*
Risk Factors
Socioeconomic Factors

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