| Does caffeine impair cerebral oxygenation and blood flow velocity in preterm infants? | |
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MedLine Citation:
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PMID: 20412101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of the study is to assess the effects of an intravenous 10 mg/kg loading dose of caffeine base in cerebral oxygenation, cerebral Doppler blood flow velocity and cardiac output in preterm infants. METHODS: Preterm neonates <34 weeks gestation were investigated at 1 and 4 h following the loading dose of caffeine using Doppler cerebral sonography, cardiac echocardiography and cerebral spatially resolved near-infrared spectroscopy. RESULTS: Forty infants were studied with a mean gestational age (mean ± standard deviation) of 27.7 (±2.5) weeks, birth weight of 1155 (±431) g and a postnatal age of 2.8 (±2.2) days. Mean Anterior Cerebral Artery peak and time average mean blood flow velocity fell significantly by 14% and 17.7%, respectively at 1 h post-caffeine loading dose, which recovered partially by 4 h. Cerebral Tissue Oxygenation Index fell from pre-dose levels by 9.5% at 1 h with partial recovery to 4.9% reduced at 4 h post-dose. There were no significant changes in left or right ventricular output, transcutaneous oxygen saturation, transcutaneous PCO(2) or total vascular resistance. CONCLUSIONS: A loading dose of 10 mg/kg caffeine base resulted in significant reduction at 1 h post-dose in cerebral oxygenation and cerebral blood flow velocity with partial recovery at 4 h. |
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Authors:
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M B Tracy; J Klimek; M Hinder; G Ponnampalam; S K Tracy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1319-23 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s)/Journal Compilation © 2010 Foundation Acta Paediatrica. |
Affiliation:
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Nepean Hospital Sydney West Area Health Service, Sydney, NSW, Australia. mark.tracy@ozemail.com.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Brain / blood supply*, drug effects Caffeine / administration & dosage, adverse effects* Cerebrovascular Circulation / drug effects* Dose-Response Relationship, Drug Humans Infant, Newborn Infant, Premature* Oxygen Consumption Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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