Document Detail


Does brain swelling increase estimated specific gravity?
MedLine Citation:
PMID:  18818888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: At the acute phase of traumatic brain injury (TBI), brain swelling contributes substantially to the development of secondary neurological lesions. Elucidating the pathophysiology of brain swelling is crucial to improve TBI management. In a previous study, specific gravity (SG) of the noncontused hemisphere, as estimated by computed tomography (CT), was higher in patients with high Marshall CT scores and severe brain swelling. The aim of this study was to investigate the relationship between estimated specific gravity (eSG) and clinical variable suggestive of brain swelling. DESIGN: Retrospective study of data from a prospectively established database. SETTING: Neurology ICU in a teaching hospital in Paris, France. PARTICIPANTS: We studied 20 patients with severe traumatic brain injury (TBI), 20 patients with high-grade subarachnoid hemorrhage (SAH) presenting similar brain-swelling criteria, 20 patients with low-grade SAH, and 20 healthy controls. INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Estimated brain specific gravity was acquired from CT images obtained at ICU admission. eSG was estimated in the overall intracerebral content and in a region-of-interest composed of white matter and the diencephalon. eSG in the region of interest was significantly higher in the TBI patients than in the high-grade SAH patients (1.0350 +/- 0.0041 vs. 1.0310 +/- 0.0019 g/ml, P < 0.05). eSG was similar in the high-grade SAH, low-grade SAH, and control groups. CONCLUSIONS: Our findings do not support a causal link between brain swelling and eSG elevation. The eSG increase in severe TBI patients is not due to brain swelling.
Authors:
Vincent Degos; Ana-Rosa Pereira; Thomas Lescot; Paola Sanchez-Peña; Mounir Daoudi; Abderrezak Zouaoui; Pierre Coriat; Louis Puybasset
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-26
Journal Detail:
Title:  Neurocritical care     Volume:  9     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  338-43     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Pierre and Marie Curie Paris 6 University, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Edema / etiology,  physiopathology*,  radiography
Brain Injuries / complications,  physiopathology*,  radiography*
Cohort Studies
Databases, Factual
Female
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors
Severity of Illness Index
Specific Gravity
Subarachnoid Hemorrhage / complications,  physiopathology*,  radiography*
Tomography, X-Ray Computed
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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