| Does blood pressure lowering treatment prevents dementia or cognitive decline in patients with cardiovascular and cerebrovascular disease? | |
| | |
MedLine Citation:
|
PMID: 15760634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is increasing evidence that both hypertension and stroke play important roles in the development of cognitive decline and dementia. Despite five high-quality randomised controlled trials (RCTs) in this area to date, there remains uncertainty about the role of blood pressure lowering therapy in the prevention of cognitive decline and dementia. It appears that lack of definitive results from these trials can be explained on the basis of (a) insufficient power to detect modest treatment effects; (b) measurement error in the diagnosis of dementia; (c) variations in the treatment effects between different types of antihypertensive agents; and (d) bias due to missing data, variation in baseline factors such as levels of blood pressure, and the inclusion of patients with cognitive impairment at entry. Preliminary meta-analysis of RCTs supports the hypothesis that blood pressure lowering may prevent dementia in high-risk patients, that is those with vascular disease. However, a meta-analysis of individual patient data (IPD) from these, and other relevant trials in patients with vascular disease, would provide much more reliable data. If the hypothesis were confirmed, it would certainly be of considerable importance not only in terms of our understanding of the aetiology of dementia, but also in promoting blood pressure lowering strategies for broader public health good. |
| | |
Authors:
|
Valery Feigin; Yogini Ratnasabapathy; Craig Anderson |
Related Documents
:
|
18481414 - Prevalence of elevated blood pressure in students attending a college oral health program. 9100084 - Systemic arterial compliance is decreased in newly-diagnosed patients with coronary hea... 19847684 - Factors associated with physical activity referral completion and health outcomes. 11268234 - High-normal serum creatinine concentration is a predictor of cardiovascular risk in ess... 16953074 - Cardiovascular effects of continuous propofol infusion in horses. 9207604 - The effect of the oviduct, uterine, and in vitro environments on zona thinning in the m... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis Date: 2005-01-07 |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: 229-230 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-03-11 Completed Date: 2005-05-03 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 151-5 Citation Subset: IM |
Affiliation:
|
Clinical Trials Research Unit, University of Auckland, Private Bag 92019, Auckland, New Zealand. v.feigin@ctru.auckland.ac.nz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Antihypertensive Agents / therapeutic use* Cardiovascular Diseases / drug therapy*, psychology* Cerebrovascular Disorders / drug therapy*, psychology* Cognition Disorders / prevention & control* Dementia, Vascular / prevention & control* Female Great Britain Humans Male Middle Aged Neuropsychological Tests Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A study of statin use in the prevention of cognitive impairment of vascular origin in the UK.
Next Document: Cognitive functioning after repetitive transcranial magnetic stimulation in patients with cerebrovas...