| Does blood donor history accurately reflect the use of prescription medications? A comparison of donor history and serum toxicologic analysis. | |
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MedLine Citation:
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PMID: 16934078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Blood donor screening is performed to accomplish several goals, including donor safety during collection and recipient safety during transfusion. Donors taking certain medications such as teratogens or platelet-inhibiting drugs are deferred from donation. Studies investigating the accuracy of the donor history are limited and only provide data on select groups of drugs. This study compares the results of an extended serum toxicology analysis to the medication use reported on the donor questionnaire. STUDY DESIGN AND METHODS: Whole-blood samples were collected from 108 volunteer blood donors. A serum toxicology analysis was performed with high-performance liquid chromatography with photodiode array detection. The results were compared to those reported on the donor history questionnaire. RESULTS: The medication history was consistent with the reported medications in 96 (89%) donors. Serum toxicology testing detected medications that were not reported on the donor history form in 12 (11%) donors. Most of the donors who did not accurately report their medication use (8 or 67%) were taking psychotropic medications. CONCLUSION: Eleven percent of the donors did not fully disclose their recent medication history. Although none of the omitted medications would have been grounds for deferral, the finding of underreporting questions the reliability of donor screening. Despite a negative medication history, blood donor centers cannot assume that donors are medication-free. This study reveals a bias to omit psychotropic medications such as antidepressants and anxiolytics. |
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Authors:
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Stacy E F Melanson; Christopher P Stowell; James G Flood; Elizabeth Lee Lewandrowski; Rychard J Zak; Kent B Lewandrowski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transfusion Volume: 46 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-28 Completed Date: 2006-09-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 1402-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Anxiety Agents Antidepressive Agents Blood Donors* Blood Transfusion* / adverse effects Donor Selection* Drug Prescriptions* Humans Medical History Taking* Platelet Aggregation Inhibitors Questionnaires* Serum Teratogens |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Platelet Aggregation Inhibitors; 0/Teratogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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