| Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation? | |
| | |
MedLine Citation:
|
PMID: 21664196 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Cystic Fibrosis (CF) lung disease is characterised by an inexorable decline in lung function, punctuated by periods of symptomatic worsening known as pulmonary exacerbations (referred to here as CFPE). Despite their clinical significance, the cause of CFPE remains undetermined. It has been suggested that an increase in bacterial density may be a trigger, although this has not been shown empirically. METHODS: Here, a previously validated quantitative PCR-based approach was used to assess numbers of Pseudomonas aeruginosa and of total bacteria in respiratory secretions from patients during the period leading up to CFPE. Sputum samples collected from 12 adult CF patients were selected retrospectively to fall approximately 21, 14, 7 and 0days prior to CFPE diagnosis. In addition, the relationships between clinical parameters (FEV(1), temperature and patient reported outcome measures) and microbiological data were investigated. RESULTS: No significant changes either in total bacterial or P. aeruginosa numbers were identified prior to CFPE. Of all the correlations tested, only temperature showed a significant correlation with total bacterial numbers in the period leading to CFPE. CONCLUSIONS: These findings strongly suggest that CFPE do not generally result from increased bacterial density within the airways. Instead, data presented here are consistent with alternative models of pulmonary exacerbation. |
| | |
Authors:
|
Franziska A Stressmann; Geraint B Rogers; Peter Marsh; Andrew K Lilley; Thomas W V Daniels; Mary P Carroll; Lucas R Hoffman; Graeme Jones; Collette E Allen; Nilesh Patel; Benjamin Forbes; Andrew Tuck; Kenneth D Bruce |
Related Documents
:
|
222126 - Improvement in regional ventilation and perfusion after radiotherapy for unresectable c... 3298696 - Hemophilia and extracorporeal shock wave lithotripsy: a case report. 11296176 - The obesity hypoventilation syndrome can be treated with noninvasive mechanical ventila... 17718246 - The effect of lateral position on oxygenation in ards patients: a pilot study. 4036486 - Pancreatic function in patients with hyperparathyroidism. a study with the lundh test. 8246016 - Copper-64 metabolism in two patients with non-wilsonian movement disorders and copper d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-8 |
Journal Detail:
|
Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: - ISSN: 1873-5010 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Molecular Microbiology Research Laboratory, Institute of Pharmaceutical Sciences, 150 Stamford Street, Franklin-Wilkins Building, King's College London, London, SE1 9NH, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacological investigations of the cellular transduction pathways used by cholecystokinin to acti...
Next Document: The effect of priming a thin ideal on the subsequent perception of conceptually related body image w...