Document Detail

Does atrial fibrillation affect plasma endothelin level?
MedLine Citation:
PMID:  20865677     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atrial fibrillation (AF) may result in endocardial endothelium dysfunction. The main objective of the study was to evaluate the plasma concentration of endothelin-1 (ET-1) during persistent AF and after sinus rhythm recovery following direct-current cardioversion and to assess the predictive value of ET-1 in AF patients.
METHODS: The study group consisted of 43 patients with persistent AF and normal left ventricle systolic function who had undergone successful cardioversion. Blood samples were collected twice: 24 hours before and 24 hours after cardioversion. All patients were also examined in terms of sinus rhythm maintenance on the 30th day after cardioversion.
RESULTS: There were no differences in ET-1 plasma concentration between the persistent AF group and the control group (2.6 ± 2.9 fmol/mL vs 2.3 ± 4.5 fmol/mL, NS). Plasma ET-1 levels did not change within 24 hours after successful cardioversion (2.5 ± 2.8 fmol/mL vs 2.6 ± 2.9 fmol/mL, NS). There was no correlation between the baseline plasma levels of ET-1 in patients with persistent AF and sinus rhythm maintenance 30 days after cardioversion.
CONCLUSIONS: Persistent AF does not affect plasma ET-1 concentration in patients with normal left ventricle systolic function and with no symptoms of heart failure. There are no significant changes in plasma ET-1 level during the 24 hours after cardioversion.
Beata Wozakowska-Kapłon; Radosław Bartkowiak; Grazyna Janiszewska; Urszula Grabowska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
1st Clinical Department of Cardiology, Swietokrzyskie Centre of Cardiology, Kielce, Poland.
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MeSH Terms
Atrial Fibrillation* / blood,  diagnosis,  therapy
Biological Markers / blood*
Electric Countershock*
Endothelin-1 / blood*
Middle Aged
Predictive Value of Tests
Ventricular Function, Left
Reg. No./Substance:
0/Biological Markers; 0/Endothelin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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