Document Detail

Does an aortopulmonary shunt before repair of tetralogy of Fallot limit exercise tolerance in long-term survivors?
MedLine Citation:
PMID:  7582989     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the impact of an aortopulmonary shunt on exercise capacity in long-term survivors after total repair of tetralogy of Fallot (17.6(2.0) years' follow-up). Submaximal exercise tests, pulmonary function tests, lund diffusion tests for carbon monoxide, two-dimensional and Doppler echocardiography were performed in 12 patients with an aortopulmonary shunt (group A) and in 21 patients (group B) without a shunt before repair. There were no significant differences in two-dimensional and Doppler echocardiographic findings nor in pulmonary function. Group A showed a significantly lower diffusion capacity of the lung for carbon monoxide at rest (66.2(13.0)% versus 84.1(9.5)%; P < 0.01) and at the anaerobic threshold (71.8(11.0)% versus 87.2(9.8)%; P < 0.01) as well as a significantly reduced physical working capacity at ventilatory anaerobic threshold (1.6)(0.32) W/kg versus 2.41(0.43) W/kg; P < 0.01). A negative correlation was observed between the duration of palliative shunts and diffusion capacity of the lung for carbon monoxide at rest at ventilatory anaerobic threshold (r = -0.8635 and -0.9108 respectively). A shunt placed before definitive repair impairs the long-term working capacity, probably by diminishing the diffusion capacity of the lung for carbon monoxide, especially if the shunt is in place for more than 20 months.
R Leyh; A Böhle; H H Sievers; A Bernhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  3     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-06     Completed Date:  1995-12-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  369-74     Citation Subset:  IM    
Department of Cardiovascular Surgery, University of Kiel, Germany.
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MeSH Terms
Anaerobic Threshold / physiology
Blood Flow Velocity / physiology
Exercise Test*
Follow-Up Studies
Hemodynamics / physiology*
Lung / blood supply
Palliative Care
Postoperative Complications / mortality,  physiopathology*
Pulmonary Diffusing Capacity / physiology*
Survival Rate
Tetralogy of Fallot / mortality,  physiopathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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