Document Detail

Does an adequate control of blood pressure protect the kidney in essential hypertension?
MedLine Citation:
PMID:  1973694     Owner:  NLM     Status:  MEDLINE    
We analyzed the clinical course of 120 patients who were diagnosed as having primary hypertension and subsequently given standard stepped-care therapy (diuretic, beta-blocker and vasodilator) for 9 years. At the end of the follow-up period, 21 patients (17.5%) had developed overt proteinuria. The initial study showed no difference in systolic blood pressure, age, sex, serum creatinine and its clearance, glucose, cholesterol and triglycerides between these patients and those who had not become proteinuric, but uric acid levels and diastolic blood pressure were higher (both P less than 0.01). An adequate control of blood pressure was obtained and maintained in all patients, who had similar therapeutic needs. During the follow-up period, uric acid levels remained significantly elevated (P less than 0.01) in the proteinuric patients, while changes in serum glucose, cholesterol and triglycerides were similar in all patients. These results indicate that long-term treatment of primary hypertensives does not fully protect kidney function and that initially elevated uric acid levels could be a predictor of a poor prognosis.
L M Ruilope; J M Alcazar; E Hernandez; F Moreno; M A Martinez; J L Rodicio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  8     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-29     Completed Date:  1990-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-31     Citation Subset:  IM    
Department of Nephrology, Octubre Hospital, Madrid, Spain.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use*
Diuretics / therapeutic use*
Follow-Up Studies
Glomerular Filtration Rate
Hypertension / drug therapy*
Kidney / pathology,  physiopathology
Middle Aged
Proteinuria / prevention & control*
Time Factors
Uric Acid / blood
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Diuretics; 0/Vasodilator Agents; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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