Document Detail

Does the added benefit of ondansetron over dexamethasone, to control post-operative nausea and vomiting, justify the added cost in patients undergoing tonsillectomy and adenotonsillectomy?
MedLine Citation:
PMID:  20578607     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate comparative effectiveness of ondansteron and dexamethasone in prophylaxis of PONV in tonsillectomy and adenotonsillectomy patients. METHODS: The study was conducted at Shifa International Hospital Islamabad from 1st January to 30th June 2009, on 60 patients undergoing tonsillectomy or adenotonsillectomy, with their consent. After consecutive alternate sampling, patients were divided into two groups containing 30 patients each. Ondansteron was given in one group, and Dexamethasone in the other group, as anti emetic, at the time of induction. Episodes of PONV were recorded at three specified intervals, i.e., immediate postoperative, 6 hours after surgery and 12 hours after surgery. Data was entered on a pre-designed performa. The data was analyzed in SPSS Version 13.0. RESULTS: Ondansteron Group had a mean age of 12.7 +/- 9.54 years (5-36 years). There were 22 (73.3%) males and 8 (26.7%) females. Dexamethasone Group had a mean age of 14.8 +/- 8.4 years (5-35 years) of whom 18 (60.0%) were males and 12 (40.0%) were females. Overall 6 patients who received ondansetron had PONV compared to 7 patients in the dexamethasone group. This difference was statistically insignificant (p > 0.05). CONCLUSION: Dexamethasone was equally effective in controlling PONV in tonsillectomy and adenotonsillectomy patients. The improved benefit of using ondansetron over dexamethasone, on a regular basis, does not justify the added cost.
Mohammad Zafar Rabbani; Mohammad Nasir Ayub Khan; Rashid Qureshi; Muhammad Zubair; Mohammad Bin Pervez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  60     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  559-61     Citation Subset:  IM    
Shifa International Hospital, Islamabad.
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MeSH Terms
Adenoids / surgery*
Antiemetics / economics,  therapeutic use*
Child, Preschool
Cost-Benefit Analysis
Dexamethasone / economics,  therapeutic use*
Ondansetron / economics,  therapeutic use*
Otorhinolaryngologic Surgical Procedures / economics*
Postoperative Nausea and Vomiting / economics,  prevention & control*
Tonsillectomy / economics
Young Adult
Reg. No./Substance:
0/Antiemetics; 50-02-2/Dexamethasone; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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