Document Detail


Does tranexamic acid save blood in minimally invasive total knee arthroplasty?
MedLine Citation:
PMID:  21286886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Tranexamic acid (TEA) reportedly reduces perioperative blood loss in TKA. However, whether it does so in minimally invasive TKA is not clear.
QUESTIONS/PURPOSES: We asked whether TEA would reduce blood loss and blood transfusion requirements after minimally invasive TKA.
PATIENTS AND METHODS: We prospectively enrolled 100 patients who underwent minimally invasive TKAs: 50 received one intravenous injection of TEA before deflation of the tourniquet and a control group of 50 patients received an equivalent volume of placebo. We compared changes in hemoglobin, postoperative drainage, total blood loss, and transfusion rates between the two groups.
RESULTS: The total blood loss was less for patients in the TEA group than for the control group: 833 mL (374-1014 mL) versus 1453 mL (733-2537 mL), respectively. The rate of blood transfusion also was less for patients in the TEA group than in the control group (4% versus 20%). The hemoglobin levels on the second and fourth postoperative days were greater for patients in the TEA group than in the control group.
CONCLUSIONS: Our data suggest one intraoperative injection of TEA decreased the total blood loss and need for transfusion after minimally invasive TKA.
LEVEL OF EVIDENCE: Level II, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Authors:
Po-Chun Lin; Chi-Hsiang Hsu; Wun-Schen Chen; Jun-Wen Wang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-01
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  469     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-08-09     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1995-2002     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antifibrinolytic Agents / therapeutic use*
Blood Loss, Surgical / prevention & control*
Blood Transfusion
Female
Hemoglobins / analysis
Humans
Injections, Intravenous
Intraoperative Period
Male
Middle Aged
Prospective Studies
Surgical Procedures, Minimally Invasive / adverse effects,  methods*
Time Factors
Tranexamic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Hemoglobins; 1197-18-8/Tranexamic Acid
Comments/Corrections

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