Document Detail

Does Spironolactone Have a Dose-Dependent Effect on Left Ventricular Remodeling in Patients with Preserved Left Ventricular Function After an Acute Myocardial Infarction?
MedLine Citation:
PMID:  22963506     Owner:  NLM     Status:  Publisher    
AIMS: The aim of this study was to investigate the effects of spironolactone on left ventricular (LV) remodeling in patients with preserved LV function following acute myocardial infarction (AMI). METHODS AND RESULTS: Successfully revascularized patients (n=186) with acute ST elevation MI (STEMI) were included in the study. Patients were randomly divided into three groups, each of which was administered a different dose of spironolactone (12.5 mg, 25 mg or none). Echocardiography was performed within the first three days and at six months after MI. Echocardiography control was performed on 160 patients at a six month follow-up. The mean left ventricular ejection fraction (LVEF) increased significantly in all groups, but no significant difference was observed between groups (p=0.13). At the end of the sixth month, the myocardial performance index (MPI) had improved in each of the three groups, but no significant difference was found between groups (F=2.00, p=0.15). The mean LV peak systolic velocities (Sm) increased only in the control group during the follow-up period, but there is no significant difference between groups (F=1.79, p=0.18). The left ventricular end systolic volume index (LVESVI) and the left ventricular end diastolic volume index (LVEDVI) did not change significantly compared to the basal values between groups (F=0.05, p=0.81 and F=1.03, p=0.31, respectively). CONCLUSION: In conclusion, spironolactone dosages of up to 25 mg do not augment optimal medical treatment for LV remodeling in patients with preserved cardiac functions after AMI. © 2012 Blackwell Publishing Ltd.
Mehmet Akif Vatankulu; Ahmet Bacaksız; Osman Sonmez; Yusuf Alıhanoglu; Fatih Koc; Kenan Demır; Enes Elvin Gul; Murat Turfan; Abdurrahman Tasal; Mehmet Kayrak; Mehmet Yazıcı; Kurtulus Ozdemır
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-11
Journal Detail:
Title:  Cardiovascular therapeutics     Volume:  -     ISSN:  1755-5922     ISO Abbreviation:  Cardiovasc Ther     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101319630     Medline TA:  Cardiovasc Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Bezmialem Vakif University, Faculty of Medicine, Cardiology Department, Istanbul, Turkey.
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