Document Detail

Does Smoking Act as a Friend or Enemy of Blood Pressure? Let Release Pandora's Box.
MedLine Citation:
PMID:  21318159     Owner:  NLM     Status:  PubMed-not-MEDLINE    
In spite of the great number of observations which show the certainty of cardiovascular damage from smoking, the opinions on that are not yet unanimous. There is a discrepancy that could be attributed to the lack of reproducible data particularly in some epidemiological studies. On the contrary, experimental findings conducted on both animals and humans give evidence of exactly reproducible results of cardiovascular alterations and among these the course of Blood Pressure (BP). Findings identify an increase in BP of active smokers or non-smokers exposed to passive smoking, while a lot of others refer a lowering of BP due to smoking. This discrepancy could be explained as follows. Initially, a vasoconstriction mediated by nicotine causes acute but transient increase in systolic BP. This phase is followed by a decrease in BP as a consequence of depressant effects played chronically by nicotine itself. Simultaneously, carbon monoxide is acting directly on the arterial wall causing, in the long run, structurally irreversible alterations. At this time, there is a change in BP that increases again, and often constantly, its levels following chronic exposure. Changes in response to antihypertensive drugs have been observed in hypertensive smokers since smoking influences metabolic steps of the drugs.
Aurelio Leone
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Publication Detail:
Type:  Journal Article     Date:  2011-01-19
Journal Detail:
Title:  Cardiology research and practice     Volume:  2011     ISSN:  2090-0597     ISO Abbreviation:  Cardiol Res Pract     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-07-14     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101516542     Medline TA:  Cardiol Res Pract     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  264894     Citation Subset:  -    
Department of Internal Medicine, City Hospital Massa, Via Provinciale 27, 19030 Castelnuovo Magra SP, Italy.
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