Document Detail


Does Size Really Matter? The Impact of Prostate Volume on the Efficacy and Safety of GreenLight HPS™ Laser Photoselective Vaporization Prostatectomy.
MedLine Citation:
PMID:  22050493     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose: To evaluate the efficacy and safety of GreenLight HPS™ laser photoselective vaporization prostatectomy (PVP) for the treatment of benign prostatic hyperplasia (BPH) in patients with different prostate volumes. Material and Methods: Between July 2006 and February 2011, 207 consecutive patients were identified from a prospectively maintained urologic database. Based on preoperative transrectal ultrasound (TRUS) measured prostate volume, patients were stratified into two groups: ≧80 mL (group I, n=57) and <80 mL (group II, n=150). Transurethral PVP was performed using a 120W GreenLight HPS™ side-firing laser system. American Urological Association Symptom Score (AUASS), Quality of Life (QoL) score, maximum flow rate (Qmax) and post void residual (PVR) volume were measured preoperatively and at 1 and 4 weeks and 3, 6, 12, 18, 24 and 36 months postoperatively. Results: Among the preoperative parameters evaluated, there were significant differences (p<0.05) in the incidence of preoperative urinary retention (I: 24.6%; II: 7.3%), serum PSA (I: 4.5±2.7; II: 1.8±1.9 ng/mL), QoL (I: 4.2±1.1; II: 4.7±0.9) and mean prostate volume (I: 118.1±37.9; II: 48.5±15.5 mL), while AUASS, Qmax and PVR were similar (p>0.05) between groups. Significant differences (p<0.05) in laser utilization (I: 22.8±13.3; II: 10.4±6.4 minutes) and energy usage (I: 152.7±90.6; II: 70.9±44.8 kJ) were also noted. Clinical outcomes (AUASS, QoL, Qmax and PVR) showed immediate and stable improvement from baseline (p<0.05) within each group, but no significant differences between the two groups were observed during the follow-up period (p>0.05). The incidence of adverse events were low and similar in both cohorts. Conclusions: These results suggest that prostate volume has little effect on the efficacy and safety of GreenLight HPS™ laser PVP, and that this technique remains a viable surgical option for BPH, irrespective of preoperative prostate volume.
Authors:
Xiao Gu; Gino J Vricella; Massimiliano Spaliviero; Carson Wong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-3
Journal Detail:
Title:  Journal of endourology / Endourological Society     Volume:  -     ISSN:  1557-900X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807503     Medline TA:  J Endourol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Oklahoma Health Sciences Center, Department of Urology, 920 Stanton L. Young Blvd. WP3150, Oklahoma City, Oklahoma, United States, 73104, 5026446794; guxiao222@hotmail.com.
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