| Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments? | |
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MedLine Citation:
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PMID: 22096123 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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SIRT1 is proposed to contribute the control of exercise mediated increases in mitochondrial biogenesis through the deacetylation, and activation, of PGC-1α. The current Viewpoint discusses the evidence that both supports and refutes this proposed model of control. In addition, an attempt is made to reconcile apparent conflicting results from in vitro and in vivo studies. Specifically, we propose that SIRT1 plays an important role in the remodelling of predominantly glycolytic muscle towards a more oxidative phenotype. |
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Authors:
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Brendon James Gurd; Jonathan Peter Little; Christopher G R Perry |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Queens University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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