| Does Rimonabant Independently Affect Free Fatty Acid and Glucose Metabolism? | |
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MedLine Citation:
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PMID: 22170727 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Endocannabinoid receptor 1 blockade is proposed to improve metabolic complications of obesity via central and peripheral effects.Objective:Our objective was to test whether rimonabant improves insulin regulation of free fatty acid and glucose metabolism after controlling for fat loss.Design:This was a double-blind, placebo-controlled substudy of the visceral fat reduction assessed by computed tomography scan on rimonabant (VICTORIA) trial.Participants and Setting:Sixty-seven abdominally obese, metabolic syndrome volunteers age 35-70 yr participated at academic medical center general clinical research centers.Intervention:Intervention included a 12-month lifestyle weight management program plus rimonabant 20 mg/d or placebo.Main Outcome Measures:Body composition and two-step euglycemic, hyperinsulinemic clamp before and after intervention were performed. Insulin sensitivity was assessed as insulin concentration needed to suppress by 50% palmitate concentration [IC(50(palmitate))], flux [IC(50(palmitate)f], and hepatic glucose output [IC(50(HGO))] and as insulin-stimulated glucose disposal (Δ glucose disappearance per Δ insulin concentration - glucose slope).Results:Body fat decreased by 4.5 ± 2.9% (SD) in the rimonabant and 1.9 ± 4.5% in the placebo group (P < 0.005). The primary [improvement in IC(50(palmitate)) and IC(50(palmitate))f] and secondary [improvement in IC(50(HGO)) and glucose slope] outcomes were not significantly different between the rimonabant and placebo groups. Post hoc analyses revealed that 1) changes in body mass index (BMI) and IC(50(palmitate)) were correlated (P = 0.005) in the rimonabant group; this relationship was not significantly different from placebo when controlling for greater BMI loss (P = 0.5); 2) insulin-regulated glucose disposal improved in both groups (P = 0.002) and correlated with changes in BMI.Conclusions:Improvements observed in insulin regulation of free fatty acid and glucose metabolism with rimonabant treatment in humans was not greater than that predicted by weight loss alone. |
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Authors:
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Jessica Triay; Manpreet Mundi; Samuel Klein; Frederico G Toledo; Steven R Smith; Haitham Abu-Lebdeh; Michael Jensen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Mayo Clinic (J.T., M.M., H.A.-L., M.J.), Endocrinology, Rochester, Minnesota 55905; Washington University School of Medicine (S.K.), St. Louis, Missouri 63110; University of Pittsburgh (F.G.T.), Pittsburgh, Pennsylvania 15213; and Florida Hospital (S.R.S.), Winter Park, Florida 32789. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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