| Does reduced lung diffusing capacity for carbon monoxide predict the presence of pulmonary hypertension? | |
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MedLine Citation:
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PMID: 20463574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to determine whether reduced lung diffusing capacity for carbon monoxide (DLCO) predicts the presence of pulmonary hypertension (PH) in heterogeneous group of patients. METHODS: Consecutive patients who underwent pulmonary function and transthoracic echocardiographic testing within a 6-month period were retrospectively identified by chart review. Right ventricular systolic pressure (RVSP) was measured using Doppler echocardiography. PH was defined as a RVSP >30 mm Hg. Patients were divided into 2 major groups: those whose RVSP was < or =30 mm Hg and those whose RVSP was >30 mm Hg. PH was classified as mild (RVSP = 31-40 mm Hg), moderate (RSVP = 41-60 mm Hg) and severe (RVSP >60 mm Hg). RESULTS: A total of 398 patients were entered into the study: 264 (66.3%) with PH and 134 (33.7%) without PH. Patients with PH were older, had a lower mean percentage of predicted values for forced vital capacity (%FVC), for DLCO (%DLCO) and for DLCO corrected for alveolar volume (%DLCO/VA) than those without PH. Multivariate analysis identified age and %FVC as independent predictors of PH [odds ratios and 95% confidence intervals of 1.038 (1.020-1.056) and 0.972 (0.955-0.988), respectively]. There was a weak, but significant negative correlation between RVSP and %DLCO (r = -0.205, P = 0.001), but there was no correlation between RVSP and %DLCO/VA. Neither %DLCO nor %DLCO/VA was found to be independent predictors of PH. CONCLUSION: In a heterogeneous group of patients, %DLCO and %DLCO/VA do not independently predict the presence of PH. |
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Authors:
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Kimberly S Delcour; Atul Singla; Mohammad Jarbou; Martin Alpert; Ousama Dabbagh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 340 ISSN: 1538-2990 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 54-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, University of Missouri School of Medicine, Columbia, Missouri 65212, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carbon Monoxide / metabolism* Female Humans Hypertension, Pulmonary / diagnosis* Lung / metabolism*, ultrasonography Male Middle Aged Multivariate Analysis Predictive Value of Tests Pulmonary Diffusing Capacity* ROC Curve Respiratory Function Tests Retrospective Studies Risk Factors Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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