Document Detail

Does PPI therapy predispose to Clostridium difficile infection?
MedLine Citation:
PMID:  19713988     Owner:  NLM     Status:  MEDLINE    
Clostridium difficile infection (CDI) has emerged as a problem of epidemic proportions. Previous exposure to broad-spectrum antibiotics remains the most important predisposing factor for the disease. However, PPIs are increasingly being overprescribed and recent research has, therefore, focused on the association between PPI therapy and CDI. While the data remain observational, increasing evidence exists for at least a modest association between PPI use and CDI.
Chaitanya Pant; Phillip Madonia; Anil Minocha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature reviews. Gastroenterology & hepatology     Volume:  6     ISSN:  1759-5053     ISO Abbreviation:  Nat Rev Gastroenterol Hepatol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500079     Medline TA:  Nat Rev Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-7     Citation Subset:  IM    
Louisiana State University Health Sciences Center and Overton Brooks VA Medical Center, Shreveport, LA, USA.
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MeSH Terms
Anti-Bacterial Agents / adverse effects
Clostridium difficile*
Enterocolitis, Pseudomembranous / epidemiology,  etiology*
Esophagitis / drug therapy,  metabolism
Gastric Acid / metabolism
Peptic Ulcer / drug therapy,  metabolism
Proton Pump Inhibitors / adverse effects*,  pharmacology,  therapeutic use
Risk Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Proton Pump Inhibitors

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