Document Detail


Does oxidative stress modulate left ventricular diastolic function in asymptomatic subjects with hereditary hemochromatosis?
MedLine Citation:
PMID:  19725855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Little is known about the early mechanisms mediating left ventricular (LV) diastolic dysfunction in patients with hereditary hemochromatosis (HH). However, the increased oxidative stress related to iron overload may be involved in this process, and strain rate (SR), a sensitive echocardiography-derived measure of diastolic function, may detect such changes.
AIM: we evaluated the relationship between left ventricular diastolic function measured with tissue Doppler SR and oxidative stress in asymptomatic HH subjects and control normal subjects.
MATERIALS AND METHODS: Ninety-four consecutive visits of 43 HH subjects, age 30-74 (50 +/- 10, mean +/- SD), and 37 consecutive visits of 21 normal volunteers, age 30-63 (48 +/- 8), were evaluated over a 3-year period. SR was obtained from the basal septum in apical four-chamber views. All patients had confirmed C282Y homozygosity, a documented history of iron overload, and were New York Heart Association functional class I. Normal volunteers lacked HFE gene mutations causing HH.
RESULTS: In the HH subjects, the SR demonstrated moderate but significant correlations with biomarkers of oxidative stress; however, no correlations were noted in normal subjects. The biomarkers of iron overload per se did not show significant correlations with the SR.
CONCLUSION: Although our study was limited by the relatively small subject number, these results suggest that a possible role of oxidative stress to affect LV diastolic function in asymptomatic HH subjects and SR imaging may be a sensitive measure to detect that effect.
Authors:
Yukitaka Shizukuda; Charles D Bolan; Dorothy J Tripodi; Vandana Sachdev; Tammy T Nguyen; Gilberto Botello; Yu-Ying Yau; Stanislav Sidenko; Ernst Inez; Mir I Ali; Myron A Waclawiw; Susan F Leitman; Douglas R Rosing
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2009-08-28
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  26     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-02     Revised Date:  2012-09-24    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1153-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. shizukya@uc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Elasticity Imaging Techniques
Female
Hemochromatosis / complications*,  diagnosis,  genetics*
Histocompatibility Antigens Class I / genetics*
Humans
Male
Membrane Proteins / genetics*
Middle Aged
Oxidative Stress / genetics*
Stroke Volume*
Ventricular Dysfunction, Left / diagnosis,  etiology*,  genetics*
Grant Support
ID/Acronym/Agency:
Z99 HL999999/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/HFE protein, human; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins
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