Document Detail


Does Microenvironment Contribute to the Etiology of Estrogen Receptor-Negative Breast Cancer?
MedLine Citation:
PMID:  23325583     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
What dictates the prevalence of certain types of breast cancer, which are classified by markers, particularly estrogen receptor (ER), expression profiles such as basal or luminal, and genetic alterations such as HER2 amplification, in particular populations is not well understood. It is increasingly evident that microenvironment disruption is highly intertwined with cancer progression. Here, the idea that microenvironment shapes the course of carcinogenesis, and hence breast cancer subtype, is discussed. Aggressive, basal-like, ER-negative breast tumors occur in younger women, African-American women, women who carry BRCA1 mutation, and women exposed to ionizing radiation. Recent experimental studies using ionizing radiation, a well-documented environmental exposure, suggest that certain processes in the microenvironment strongly favor the development of ER-negative tumors. Understanding the contribution of tissue microenvironment during carcinogenesis could lead to prevention strategies that are personalized to age, agent, and exposure to reduce the risk of aggressive breast cancer. Clin Cancer Res; 19(3); 1-8. ©2012 AACR.
Authors:
Mary Helen Barcellos-Hoff
Related Documents :
2808713 - Utilization of therapeutic embolization in haemorrhage caused by carcinoma of the tongue.
24348743 - Transformation of physical dvhs to radiobiologically equivalent ones in hypofractionate...
18696273 - Thyroid cancer, thyroiditis and dietary iodine: a review based on the salta, argentina ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  -     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Author's Affiliation: Department of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Massively Parallel Tumor Multigene Sequencing to Evaluate Response to Panitumumab in a Randomized Ph...
Next Document:  Cost-effectiveness of provider-based HIV partner notification in urban Malawi.