Document Detail


Does MSI-low exist?
MedLine Citation:
PMID:  12081205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microsatellite instability is a well-recognised phenomenon. Ten to 15% of sporadic colorectal cancers with a high level of MSI form a well defined group with distinct clinicopathological features. The set of tumours with low level of microsatellite instability (MSI-low), though widely referred to, is not a clearly defined group. The definitions of MSI-low have varied among groups and between different studies from the same group. Some studies have found associations between the MSI-L phenotype and molecular features, notably a higher frequency of K-ras mutations, and, possibly, methylation of methylguanine methyltransferase. Two recent independent studies, however, showed respectively that 68% and 79%, non-MSI-H cancers showed some MSI and could therefore be classed nominally as MSI-L. There was no evidence for a qualitatively discrete MSI-L group, but quantitative differences in the level of MSI were found.
Authors:
Ian Tomlinson; Sarah Halford; Lauri Aaltonen; Nicholas Hawkins; Robyn Ward
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of pathology     Volume:  197     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-25     Completed Date:  2002-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
Affiliation:
Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, UK. i.tomlinson@icrf.icnet.uk
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MeSH Terms
Descriptor/Qualifier:
Colorectal Neoplasms / genetics*,  pathology
Humans
Microsatellite Repeats*
Comments/Corrections
Comment In:
J Pathol. 2003 Feb;199(2):267-9; author reply 269-70   [PMID:  12533841 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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