Document Detail

[Does long-term asbestos exposure cause an obstructive ventilation pattern?].
MedLine Citation:
PMID:  20635315     Owner:  NLM     Status:  In-Process    
This review shows that long-term exposure to asbestos-containing dust leads not only to a reduction of lung volume as well as to limitations of forced expiratory flows, such as FEF (50) and FEF (75), but also to increased frequencies of FEV (1)/FVC, and elevated airway resistance. There is evidence for significant dose-response relationships and an increase in functional changes in parallel to an increase due to the latency period. Remarkably, even asbestos workers without radiologically detectable pleural or parenchymal changes already show these functional impairments. In non-smokers, asbestos-induced lung function impairment is usually small on average, although some of these subjects show functional impairment of clinical relevance in the pathological range. In asbestos workers who also smoke, due to synergistic effects, lung function, especially of the peripheral airways, is highly significantly reduced. The use of inappropriate reference values, healthy worker effects, and airway trapping lead to an underestimation of asbestos-induced lung function impairments. There are no differences among the various occupations associated with asbestos exposure.
X Baur; U Manuwald; D Wilken
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Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-07-15
Journal Detail:
Title:  Pneumologie (Stuttgart, Germany)     Volume:  64     ISSN:  1438-8790     ISO Abbreviation:  Pneumologie     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906641     Medline TA:  Pneumologie     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  736-44     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Ordinariat für Arbeitsmedizin, Universitätsklinikum Hamburg-Eppendorf, Zentralinstitut für Arbeitsmedizinund Maritime Medizin, Seewartenstrasse 10, Hamburg.
Vernacular Title:
Verursacht langjährige Asbestexposition eine obstruktive Ventilationsstörung?
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