Document Detail

Does Location of Epicardial Adipose Tissue Correspond to Endocardial High Dominant Frequency or Complex Fractionated Atrial Electrogram Sites During Atrial Fibrillation?
MedLine Citation:
PMID:  22772897     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Although increased epicardial adipose tissue (EAT) volume is known to be associated with increased prevalence of atrial fibrillation (AF), the exact mechanisms are unclear. Therefore, we investigated whether EAT locations were associated with high dominant frequency (DF) sites and/or complicated fractionated atrial electrogram (CFAE) sites during AF. METHODS AND RESULTS: -Three-dimensional reconstruction CT images depicting EAT volumes (obtained by 320-detector-row multislice CT) were merged with NavX-based DF and CFAE maps obtained during AF for 16 patients with paroxysmal AF (PAF) and 18 patients with persistent AF (PerAF). Agreement between locations of the EAT, especially EAT surrounding the left atrium (LA-EAT), and of high DF or CFAE sites was quantified. In addition, serum biomarker levels were determined. LA-EAT volumes were significantly greater in patients with PerAF than in patients with PAF [52.9 cm(3) (95% confidence interval [CI], 44.2-61.5) vs. 34.8 cm(3) (95%CI, 26.6-43.0); P=0.007]. Serum high-sensitivity C-reactive protein and interleukin-6 levels were significantly higher in PerAF patients than in PAF patients [median hs-CRP, 969 ng/mL (interquartile range [IQR], 307-1678) vs. 320 ng/mL (IQR 120-660), P=0.008; median IL-6, 2.4 pg/mL (IQR 1.7-3.2) vs. 1.3 (IQR 0.8-2.4) pg/mL, P=0.017]. EAT locations were in excellent agreement with high DF sites [kappa=0.77 (95%CI, 0.71-0.82)], but poor agreement with CFAE sites [kappa=0.22 (95%CI, 0.13-0.31)]. CONCLUSIONS: -Increased EAT volume and elevation of inflammatory biomarkers are noted in PerAF rather than PAF patients. High DF sites are located adjacent to EAT sites. Thus, EAT may be involved in the maintenance of AF.
Koichi Nagashima; Yasuo Okumura; Ichiro Watanabe; Toshiko Nakai; Kimie Ohkubo; Masayoshi Kofune; Hiroaki Mano; Kazumasa Sonoda; Takafumi Hiro; Mizuki Nikaido; Atsushi Hirayama
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-6
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Nihon University School of Medicine, Tokyo, Japan;
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