| Does LD100 E coli shock cause myocardial failure? | |
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MedLine Citation:
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PMID: 7039859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have documented that myocardial dysfunction occurs in canine endotoxin shock and have designed this study to determine the effect of lethal live E coli-induced shock on the myocardium. Small adult heart "donor" dogs (wt range 6-9 kg) were infused with LD100 E coli (N = 12) or saline (N = 16) for 30 minutes. Two hours later, heart transfer surgery was initiated and once completed the isolated working left ventricle was allowed to equilibrate in the extracorporeal circuit of a "support" dog (wt range 22-32 kg). Myocardial performance was then evaluated by changing mean aortic pressure while controlling cardiac output. Three to five hours after E coli infusion, marked myocardial dysfunction occurred in 75% of the hearts as evidenced by increased left ventricular and diastolic pressures and depressed peak positive and negative dP/dt at every mean aortic pressure tested compared with control hearts. Myocardial efficiency and power were depressed, oxygen uptake was elevated, and coronary blood flow was unchanged in E coli-treated compared with control hearts. Data support the presence of heart dysfunction in gram-negative septic shock. |
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Authors:
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L T Archer; B A Benjamin; B K Beller-Todd; D J Brackett; M F Wilson; L B Hinshaw |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulatory shock Volume: 9 ISSN: 0092-6213 ISO Abbreviation: Circ. Shock Publication Date: 1982 |
Date Detail:
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Created Date: 1982-06-14 Completed Date: 1982-06-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0414112 Medline TA: Circ Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 7-16 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation Dogs Endotoxins / administration & dosage Escherichia coli* Heart Failure / etiology* Myocardial Contraction Oxygen Consumption Shock, Septic / complications*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL 07340/HL/NHLBI NIH HHS; HL/AI 24590/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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