Document Detail

Does LD100 E coli shock cause myocardial failure?
MedLine Citation:
PMID:  7039859     Owner:  NLM     Status:  MEDLINE    
We have documented that myocardial dysfunction occurs in canine endotoxin shock and have designed this study to determine the effect of lethal live E coli-induced shock on the myocardium. Small adult heart "donor" dogs (wt range 6-9 kg) were infused with LD100 E coli (N = 12) or saline (N = 16) for 30 minutes. Two hours later, heart transfer surgery was initiated and once completed the isolated working left ventricle was allowed to equilibrate in the extracorporeal circuit of a "support" dog (wt range 22-32 kg). Myocardial performance was then evaluated by changing mean aortic pressure while controlling cardiac output. Three to five hours after E coli infusion, marked myocardial dysfunction occurred in 75% of the hearts as evidenced by increased left ventricular and diastolic pressures and depressed peak positive and negative dP/dt at every mean aortic pressure tested compared with control hearts. Myocardial efficiency and power were depressed, oxygen uptake was elevated, and coronary blood flow was unchanged in E coli-treated compared with control hearts. Data support the presence of heart dysfunction in gram-negative septic shock.
L T Archer; B A Benjamin; B K Beller-Todd; D J Brackett; M F Wilson; L B Hinshaw
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  9     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1982  
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-16     Citation Subset:  IM    
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MeSH Terms
Coronary Circulation
Endotoxins / administration & dosage
Escherichia coli*
Heart Failure / etiology*
Myocardial Contraction
Oxygen Consumption
Shock, Septic / complications*,  physiopathology
Grant Support
Reg. No./Substance:

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