Document Detail


Well-trained, healthy triathletes experience no adverse health risks regarding oxidative stress and DNA damage by participating in an ultra-endurance event.
MedLine Citation:
PMID:  19766696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Also physical exercise in general is accepted to be protective, acute and strenuous exercise has been shown to induce oxidative stress. Enhanced formation of free radicals leads to oxidation of macromolecules and to DNA damage. On the other hand ultra-endurance events which require strenuous exercise are very popular and the number of participants is continuously increasing worldwide. Since only few data exists on Ironman triathletes, who are prototypes of ultra-endurance athletes, this study was aimed at assessing the risk of oxidative stress and DNA damage after finishing a triathlon and to predict a possible health risk. Blood samples of 42 male athletes were taken 2 days before, within 20 min after the race, 1, 5 and 19 days post-race. Oxidative stress marker increased only moderately after the race and returned to baseline after 5 days. Marker of DNA damage measured by the SCGE assay with and without restriction enzymes as well as by the sister chromatid exchange assay did either show no change or deceased within the first day after the race. Due to intake during the race and the release by the cells plasma concentrations of vitamin C and α-tocopherol increased after the event and returned to baseline 1 day after. This study indicates that despite a temporary increase in some oxidative stress markers, there is no persistent oxidative stress and no DNA damage in response to an Ironman triathlon in trained athletes, mainly due to an appropriate antioxidant intake and general protective alterations in the antioxidant defence system.
Authors:
Karl-Heinz Wagner; Stefanie Reichhold; Christine Hölzl; Siegfried Knasmüller; Lukas Nics; Marlies Meisel; Oliver Neubauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Toxicology     Volume:  278     ISSN:  1879-3185     ISO Abbreviation:  Toxicology     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. karl-heinz.wagner@univie.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / administration & dosage
Ascorbic Acid / administration & dosage,  blood*
Athletes
Bicycling
Comet Assay
DNA Damage*
Humans
Male
Oxidative Stress*
Physical Endurance*
Running
Sister Chromatid Exchange
Swimming
Time Factors
alpha-Tocopherol / administration & dosage,  blood*
Chemical
Reg. No./Substance:
0/Antioxidants; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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