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Does HLA-B*2706 protect against ankylosing spondylitis? A meta-analysis.
MedLine Citation:
PMID:  22324941     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The human leukocyte antigen (HLA)-B*2706 is a relatively rare subtype of HLA-B27. In contrast to most HLA-B27 subtypes, some studies have reported HLA-B*2706 to be protective against ankylosing spondylitis (AS). A systematic review and a meta-analysis of available studies was performed to investigate the association of HLA-B*2706 with AS. After literature review a random effect meta-analysis was performed. No studies were found comparing the frequency of HLA-B*2706 in AS patients and controls. Meta-analysis of seven studies using HLA-B27-positive AS patients and controls showed a protective effect of HLA-B*2706 on development of AS in HLA-B27 individuals (odds ratio = 0.128, 95% CI = 0.043-0.378, P < 0.001). The results of the meta-analysis of HLA-B*2706 in HLA-B27-positive patients and controls is preliminary evidence of a protective effect of HLA-B*2706 against AS in the population. There is a clear need for additional studies on HLA-B*2706 in AS. Due to the fact that HLA-B*2706 is more or less restricted to Southeast Asia, researchers in this part of the world may have an essential role in performing these studies.
Authors:
Floris Alexander Van Gaalen
Publication Detail:
Type:  Journal Article     Date:  2011-10-18
Journal Detail:
Title:  International journal of rheumatic diseases     Volume:  15     ISSN:  1756-185X     ISO Abbreviation:  Int J Rheum Dis     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474930     Medline TA:  Int J Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  8-12     Citation Subset:  IM    
Copyright Information:
© 2011 The Author. International Journal of Rheumatic Diseases © 2011 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
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