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Does Extensive Upper Abdomen Surgery During Primary Cytoreduction Impact on Long-term Quality of Life?
MedLine Citation:
PMID:  23429485     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: The objective of this study was to evaluate the feasibility in terms of safety and quality of life in a sample of Italian patients affected by advanced ovarian cancer and submitted to either extensive upper abdomen or standard surgery, through validated questionnaires.
METHODS: From January 2006 to November 2011, a prospective, observational study was conducted to compare quality of life in patients affected by advanced ovarian cancer and submitted to primary cytoreduction in the Division of Gynecology of the University Campus Bio-Medico of Rome. After surgery patients were stratified into 2 groups (group A: standard surgery or group B: extensive upper abdomen surgery). All patients were submitted to standard chemotherapy. At completion of treatment, during the first follow-up visit, all eligible patients were asked to fill in Quality of Life Questionnaire-C30 (QLQ-C30) (version 3.0) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-OV28 (QLQ-OV28) questionnaires.
RESULTS: Eighty-nine patients were enrolled into our study. Nine were excluded, so finally 80 patients were considered in this study. Group A included 40 patients and underwent standard surgery (pelvic surgery); group B, included 40 patients and underwent extensive upper abdomen surgery. There were no statistical differences in terms of major surgical complication rates (15% vs 10%). We registered same times of beginning of chemotherapy (median, 19 vs 21 days) and no severe related toxicities. Quality-of-life scores of both questionnaires were comparable between groups, with the exception of Global Health Status in QLC-30.
CONCLUSIONS: Upper abdomen surgery is a feasible and safe therapeutic option. Patients present same times of beginning of chemotherapy without an increase in chemorelated toxicities and experience the same general quality of life.
Roberto Angioli; Francesco Plotti; Alessia Aloisi; Stella Capriglione; Corrado Terranova; Roberto Ricciardi; Roberto Montera; Marzio Angelo Zullo; Virginia Rasi; Pierluigi Benedetti-Panici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  23     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-7     Citation Subset:  IM    
*Department of Obstetrics and Gynaecology Campus Bio Medico, †Department of Obstetrics and Gynaecology "Tor Vergata," and ‡Department of Obstetrics and Gynaecology "Sapienza," University of Rome, Rome, Italy.
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