Document Detail

Does erythrocyte blood transfusion prevent acute kidney injury? Propensity-matched case control analysis.
MedLine Citation:
PMID:  20966666     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute kidney injury is a common occurrence in intensive care unit patients with a reported incidence of 11-67% and is associated with an increased risk of death. In other patient populations, erythrocyte transfusion has been associated with increased risk of adverse outcomes including sepsis, multisystem organ dysfunction, and death. The purpose of this study was to determine the effect of erythrocyte transfusion on the development of acute kidney injury. METHODS: This was a retrospective analysis of prospectively collected data that used propensity matched transfused and nontransfused patients. Propensity matching was done using semiparsimonious logistic regression. McNemar test for nonindependent data sets was used to compare groups. RESULTS: Four hundred two patients from a trial on fluid management in patients with acute lung injury were matched. 38% of transfused patients had a rise in creatinine the day after transfusion compared with 33% of their nontransfused matches (P = 0.315). By day 7, creatinine had increased in 51% of transfused patients compared with 52% in nontransfused patients (P = 0.832). The incidences of renal risk, injury, and failure were 39 (19%), 27 (13%), and 11 (5%) in the transfused group and 38 (19%), 24 (12%), and 11 (5%) in the nontransfused group, P = 1.00, 0.785, and 1.00, respectively. CONCLUSIONS: Transfusion of erythrocytes to patients with acute lung injury had no effect on the development of acute kidney injury.
Milo Engoren
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  113     ISSN:  1528-1175     ISO Abbreviation:  Anesthesiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1126-33     Citation Subset:  AIM; IM    
Department of Anesthesiology, Mercy St. Vincent Medical Center, Toledo, OH, USA.
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MeSH Terms
Acute Lung Injury / blood,  complications,  therapy
Case-Control Studies
Congenital Hypothyroidism / blood
Endpoint Determination / methods
Erythrocyte Transfusion / adverse effects,  methods*
Kidney Failure, Acute / blood,  etiology*,  prevention & control*
Middle Aged
Prospective Studies
Randomized Controlled Trials as Topic / methods
Retrospective Studies
Treatment Outcome
Comment In:
Anesthesiology. 2010 Nov;113(5):1012-3   [PMID:  20881590 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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