| Does erythrocyte blood transfusion prevent acute kidney injury? Propensity-matched case control analysis. | |
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MedLine Citation:
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PMID: 20966666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute kidney injury is a common occurrence in intensive care unit patients with a reported incidence of 11-67% and is associated with an increased risk of death. In other patient populations, erythrocyte transfusion has been associated with increased risk of adverse outcomes including sepsis, multisystem organ dysfunction, and death. The purpose of this study was to determine the effect of erythrocyte transfusion on the development of acute kidney injury. METHODS: This was a retrospective analysis of prospectively collected data that used propensity matched transfused and nontransfused patients. Propensity matching was done using semiparsimonious logistic regression. McNemar test for nonindependent data sets was used to compare groups. RESULTS: Four hundred two patients from a trial on fluid management in patients with acute lung injury were matched. 38% of transfused patients had a rise in creatinine the day after transfusion compared with 33% of their nontransfused matches (P = 0.315). By day 7, creatinine had increased in 51% of transfused patients compared with 52% in nontransfused patients (P = 0.832). The incidences of renal risk, injury, and failure were 39 (19%), 27 (13%), and 11 (5%) in the transfused group and 38 (19%), 24 (12%), and 11 (5%) in the nontransfused group, P = 1.00, 0.785, and 1.00, respectively. CONCLUSIONS: Transfusion of erythrocytes to patients with acute lung injury had no effect on the development of acute kidney injury. |
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Authors:
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Milo Engoren |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Anesthesiology Volume: 113 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 1126-33 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology, Mercy St. Vincent Medical Center, Toledo, OH, USA. engoren@pol.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
/
blood,
complications,
therapy Adult Aged Case-Control Studies Congenital Hypothyroidism / blood Endpoint Determination / methods Erythrocyte Transfusion / adverse effects, methods* Female Humans Kidney Failure, Acute / blood, etiology*, prevention & control* Male Middle Aged Prospective Studies Randomized Controlled Trials as Topic / methods Retrospective Studies Treatment Outcome |
| Comments/Corrections | |
Comment In:
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Anesthesiology. 2010 Nov;113(5):1012-3
[PMID:
20881590
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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