| Does EVAR alter the rate of cardiovascular events in patients with abdominal aortic aneurysm considered unfit for open repair? Results from the randomised EVAR trial 2. | |
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MedLine Citation:
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PMID: 20096611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate whether endovascular aneurysm repair (EVAR) influences the rate of cardiovascular events (fatal or non-fatal myocardial infarction or stroke) in patients with abdominal aortic aneurysm (AAA) considered unfit for open repair. DESIGN: Randomised controlled trial. MATERIALS: Between 1999 and 2004, 404 patients with large AAA considered unfit for open repair were randomised to EVAR or no surgical intervention across 33 UK hospitals and followed until July 2009. METHODS: The Customised Probability Index was used to determine fitness for each patient and Cox regression was used to compare time to first cardiovascular event between randomised groups and levels of fitness. RESULTS: During an average of 2.8 years of follow-up, 67 first cardiovascular events occurred with a non-significantly higher event rate in the EVAR group compared to the no intervention group (6.6 versus 5.1 events per 100 person years); adjusted hazard ratio 1.42 [95% CI 0.87-2.34], p=0.156. There was no evidence to suggest that the hazard ratio between randomised groups changed with level of fitness (p=0.378). CONCLUSIONS: Cardiovascular event rates were high in these unfit patients and medical therapy was sub-optimal. Events rates were slightly higher in the EVAR group but this was not statistically significant. |
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Authors:
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L C Brown; R M Greenhalgh; S G Thompson; J T Powell; |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-21 |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 39 ISSN: 1532-2165 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: England |
Other Details:
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Languages: eng Pagination: 396-402 Citation Subset: IM |
Affiliation:
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Vascular Surgery Research Group, Imperial College, 4th Floor, Charing Cross Hospital, Fulham Palace Road, London, UK. louise.brown@imperial.ac.uk |
| Data Bank Information | |
Bank Name/Acc. No.:
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ISRCTN/ISRCTN55703451 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aortic Aneurysm, Abdominal / mortality, radiography, surgery* Aortography / methods Blood Vessel Prosthesis Implantation / adverse effects*, mortality Chi-Square Distribution Female Great Britain Humans Kaplan-Meiers Estimate Male Myocardial Infarction / etiology*, mortality Patient Selection Proportional Hazards Models Risk Assessment Risk Factors Severity of Illness Index Stroke / etiology*, mortality Time Factors Tomography, X-Ray Computed Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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//Department of Health |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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