| Does EEG predict response to valproate versus lithium in patients with mania? | |
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MedLine Citation:
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PMID: 11534927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of factors may suggest that a patient with mania may respond to valproate or to lithium. However, prediction of which patients will respond to either medication remains difficult. In this study nonepileptiform EEG abnormalities in responders to each medication were investigated. Six of 20 patients (30%) responsive to lithium but not to valproate had nonepileptiform EEG abnormalities while 14 of 20 patients (70%) responsive to valproate but not to lithium had nonepileptiform EEG abnormalities. Patients presenting with mania and EEG abnormalities, particularly sharp activity, are statistically more likely (chi2 = 4.9, df = 1, p = .027) to respond to valproate than to lithium. Whether such a finding will also hold true for other anticonvulsants used to treat mania remains to be seen. |
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Authors:
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R R Reeves; F A Struve; G Patrick |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists Volume: 13 ISSN: 1040-1237 ISO Abbreviation: Ann Clin Psychiatry Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-09-05 Completed Date: 2002-02-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8911021 Medline TA: Ann Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 69-73 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, VA Medical Center, Jackson, Mississippi 39216, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Anticonvulsants / therapeutic use* Antimanic Agents / therapeutic use* Bipolar Disorder / diagnosis, drug therapy*, physiopathology* Brain / physiopathology* Electroencephalography Female Humans Lithium / therapeutic use* Male Middle Aged Psychotic Disorders / diagnosis, drug therapy, physiopathology Severity of Illness Index Valproic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Antimanic Agents; 7439-93-2/Lithium; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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