| Does Children's Oncology Group hospital membership improve survival for patients with neuroblastoma or Wilms tumor? | |
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MedLine Citation:
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PMID: 20806361 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine prognostic significance of hospital surgical volume and Children's Oncology Group (COG) membership on neuroblastoma (NBL) and Wilms tumor (WT) survival. METHODS: The Florida Cancer Data System was queried from 1981 to 2004. RESULTS: Of 869 NBL patients, 463 were treated at COG/HVC, 246 at COG/LVC, and 160 at non-COG/LVC. COG hospitals treated a larger proportion of patients <1 year of age (P = 0.002) and relatively more patients with adrenal and mediastinal tumors (P = 0.005). COG centers more frequently administered chemotherapy (72% vs. 51%, P < 0.001). Five- and 10-year survival rates were higher at COG/HVC (70.6%, 67.7%) and COG/LVC (75.8%, 72.6%) than non-COG/LVC (59.5%, 54.4%, P < 0.05). Of 790 WT patients, 395 were treated at COG/HVC, 210 at COG/LVC, and 185 at non-COG/LVC. COG hospitals treated younger patients and lower staged tumors (P < 0.05). COG centers more frequently administered chemotherapy (88% vs. 59%, P < 0.001). Five- and 10-year survival rates were higher at COG/HVC (91.3%, 89.9%) and COG/LVC (96.7%, 94.7%) than non-COG/LVC (82.4%, 81.7%, P < 0.05). Multivariate analysis demonstrated WT patients treated at non-COG hospitals, but not NBL patients, had worse survival (HR 3.107, P = 0.01). CONCLUSION: Children treated at COG hospitals had higher overall use of chemotherapy. This translated into a significantly improved survival benefit for WT. |
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Authors:
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Juan C Gutierrez; Michael C Cheung; Ying Zhuge; Leonidas G Koniaris; Juan E Sola |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: 2010-12-15 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 621-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Division of Pediatric Surgery and Surgical Oncology, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Female Florida Hospitals, Pediatric / standards Humans Infant Kidney Neoplasms / drug therapy, mortality*, surgery Male Multivariate Analysis Neuroblastoma / drug therapy, mortality*, surgery Outcome and Process Assessment (Health Care)* Survival Rate Wilms Tumor / drug therapy, mortality*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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